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The HUNT for Heart Failure Risk Score

Heart Failure Burden and Heart Failure Risk in the General Population in Norway: The HUNT for Heart Failure Risk Score

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04648852
Acronym
HUNT4HF
Enrollment
36511
Registered
2020-12-02
Start date
2017-10-01
Completion date
2023-06-30
Last updated
2025-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

risk factor, population, diagnosis, prognosis

Brief summary

In this population study aim is to evaluate risk factors for heart failure and combine these into a new heart failure risk score. Secondly, the heart failure risk score will be internally and externally validated, and compared with established heart failure risk scores. Additionally, the prevalence of heart failure as well as the distribution of the heart failure risk score in the general population will be evaluated.

Detailed description

Explore which clinical risk factors or patient characteristics in a general population that are associated with increased risk for heart failure events and combine these into a new population-based heart failure risk score (The HUNT for heart failure risk score) for predicting heart failure risk Validate the newly developed heart failure risk score internally in the HUNT2 database Compare the predictive ability of the new heart failure risk score with established heart failure risk scores (the ABC Health HF risk score, the Framingham HF risk score) and an established Norwegian cardiovascular risk score (NORRISK 2) Estimate the prevalence of likely (undiagnosed) heart failure , i.e., patients at high risk of HF, in a general population by using both the established heart failure risk scores and the newly developed heart failure risk score, and compare the heart failure event rate between those at high risk of heart failure and those with established heart failure.

Interventions

OTHERHeart failure risk estimation

Evaluation by heart failure risk score

Sponsors

Boehringer Ingelheim
CollaboratorINDUSTRY
Norwegian University of Science and Technology
CollaboratorOTHER
Vestre Viken Hospital Trust
CollaboratorOTHER
Helse Nord-Trøndelag HF
Lead SponsorOTHER

Study design

Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes

Inclusion criteria

* Participation in the third or second wave of the HUNT study

Exclusion criteria

* Not willing to participate * Missing vital data

Design outcomes

Primary

MeasureTime frameDescription
Time to incident heart failure event10 yearsTime to first heart failure hospitalization or heart failure related visit at the out-patient clinic (events defined according to the ESC 2016 heart failure guidelines)

Secondary

MeasureTime frameDescription
Time to death from any cause10 yearsTime to death from any cause
Time to first heart failure event or death from any cause10 yearsTime to first heart failure event (hospitalization or HF related visit at the out-patient clinic) or death from any cause
Validity of heart failure risk score10 yearsEvaluation of the validity of heart failure risk score

Other

MeasureTime frameDescription
Prevalence of heart failure0 daysPrevalence of heart failure in a general population
Distribution of heart failure risk score categories0 daysDistribution of the heart failure risk score categories in a general population

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026