Vision Functional Brain Networks in Patients With Hereditary Retinal Dystrophies
Conditions
Brief summary
The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.
Interventions
DEVICEIRMf-r (séquence resting state)
Functional MRI of functional brain networks
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient over 18 years old * Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique * Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme
Exclusion criteria
* Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman * Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker). * Other additional ocular pathology that can significantly affect vision * Recent eye surgery less than 3 months old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Localization and characterization of neural networks | baseline | neuronal networks description using rest and morphological functionnal MRIs |
| Evolution of neuronal networks after retinal implantation | baseline | neuronal networks description using rest and morphological functionnal MRIs |
Countries
France
Contacts
Primary ContactAmélie YAVCHITZ
Outcome results
None listed