Epigenetics in Lupus Nephritis

Unmethylated CpG-rich DNA Fragments in TLR-mediated Renal Fibrogenesis of Lupus Nephritis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04648059

Acronym

Epi_LN

Enrollment

Registered

2020-12-01

Start date

2020-12-01

Completion date

2023-06-30

Last updated

2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lupus Nephritis, Systemic Lupus Erythematosus

Keywords

Epigenetics, Methylation, Toll-like receptors, Fibrosis

Brief summary

This is a translational study for the identification of epigenetic changes detectable in sera of patients suffering from Systemic Lupus erythematosus. The aim of the study is to analyze whether circulating DNA fragments are 1) different in patients with or without Lupus nephritis and 2) present and detectable in the circulation before the development of Lupus nephritis.

Interventions

DIAGNOSTIC_TESTBlood sampling

Blood sampling will be performed to allow analyses of epigenetic markers

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosis of systemic lupus erythematosus according to the current classification criteria * a subgroup requires the presence of Lupus nephritis (no restriction to specific LN histologic subtypes)

Exclusion criteria

* patients not able or unwilling to provide written informed consent

Design outcomes

Primary

Measure	Time frame	Description
Methylated CpG-rich DNA fragments	12 months	it will be analyzed whether circulating CpG-rich DNA fragments are present in patients' blood

Countries

Germany

Contacts

Primary ContactPETER KORSTEN, MD

peter.korsten@med.uni-goettingen.de055139

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026