Ischemia Reperfusion Injury
Conditions
Brief summary
Aim of the work : Evaluation of the role of Remote Ischemic Preconditioning (RIP) on liver function in patients undergoing on-pump cardiac surgery.
Interventions
PROCEDUREremote ischemic preconditioning
3 cycles of 5-minutes inflation of a blood pressure cuff to 200mmHg (or at least to a pressure 50mm Hg higher than the systolic arterial pressure) to one upper arm, followed by5-minutes reperfusion with the cuff deflated
PROCEDURESham remote ischemic preconditioning
3cycles of upper limb pseudo ischemia (low pressure, 5-minutes blood pressure cuff inflation to a pressure of 20 mm Hg and 5-minutes cuff deflation).
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Being candidate for on-pump cardiac surgery. 2. Willing to participate in the study 3. Ages eligible for the study: 18 to 70 years. 4. Gender eligible for the study : both
Exclusion criteria
1. Patient refusal. 2. Known cause of possible liver function disturbances that includes right heart failure, acute inflammation of gallbladder or any other complication of gallstone disease. 3. Active viral and non viral hepatitis. 4. Pregnant women. 5. History of peripheral nerve disease or peripheral vascular disease of the extremities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| liver function test | 3 postoperative days | Direct Bilirubin |
Countries
Egypt
Outcome results
None listed