Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4
Conditions
Brief summary
The aim of the present study is to assess the post-operative outcomes (morbidity and mortality) in relation to preoperative data and the oncological outcomes (overall and disease-free survival) in patients with a locally advanced colon cancer (LACC) with the necessity of a multivisceral resection (MVR).
Detailed description
All patients that meet the inclusion criteria will be registered in a retrospective database from 2014 to 2019 (5 years) Data will be reported for every patients with colon cancer to have had either a resection of another organ or structure in addition to resection of the primary tumor, or to have had a T4 (a or b) tumour on postoperative histopathology. Data included are patient demographics, ASA score, tumor localization, preoperative imaging, neoadjuvant treatments, type of bowel resection and adjacent organs resected, tecnique (laparoscopic/laparotomic), postoperative complications and 30-day mortality, histopathology data including TNM scoring, completeness of surgical procedure (R0 to R2) and infiltration of tumor cells in resected tissues, adjuvant oncological treatments, and long term follow-up data on local and distant recurrence and survival.
Interventions
PROCEDUREMultivisceral resection
Multivisceral resection for locally advanced colon cancer.
Sponsors
Santo Spirito Hospital, Italy
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 aa * Patients with a locally advanced colon cancer (LACC) with the necessity of a multivisceral resection (MVR).
Exclusion criteria
* Stage IV * Rectal cancer * Emergency surgery (\<48 hours from admission) * ASA \> III
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative morbidity | 30 days | I evaluate peri and post-operative surgical (e.g. intraabdominal collection, fistula, anastomotic leak) and medical (e.g. pneumoniae, deep vein thrombosis) complications |
| Postoperative mortality | 30 days | I evaluate in-hospital and 30-day mortality correlate to the intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | 5 years | The length of time from the intervention that patients diagnosed with a T4 colon cancer are still alive. |
| Disease Free Survival | 5 years | The measure of time after treatment during which no sign of recurrence (local or metastatic) is found. |
Outcome results
None listed