Coronary Hemodynamics by Coronary Angiography

Estimation of Coronary Artery Hemodynamic Profiles Using Cineangiography Technique

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04646278

Acronym

ESCARGOT

Enrollment

Registered

2020-11-27

Start date

2017-04-11

Completion date

2020-03-25

Last updated

2020-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

coronary artery disease, Index of microcirculatory resistance, TIMI frame count, Fractional flow reserve, Coronary flow reserve

Brief summary

Study for developing techniques to evaluate coronary artery hemodynamic profiles by conventional angiography without more dedicated measuring devices.

Detailed description

\* Methods: Compare TIMI frame count, coronary clearance frame count in baseline/hyperemic coronary angiography with FFR, CFR, IMR and derive correlation, receiver-operating characteristic curve to find new tools estimating coronary hemodynamics by conventional angiography only. A TIMI frame count is measured by counting the angiographic image cine frames during a head of radiocontrast column runs from the entry of left anterior descending artery (LAD) to the distal end. A coronary clearance frame count is measured by counting the angiographic image cine frames during a tail of radiocontrast column runs from the entry of LAD to the distal end. Baseline angiography is performed without any stimulation and hyperemic angiography is performed after intracoronary injection of adenosine 300ug or nicorandiol 2mg. Inclusion criteria * Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography Exclusion criteria * ST elevation myocardial infarction * Cardiogenic shock * Congestive heart failure with pulmonary edema * LVEF \< 30% * Previous history of coronary revascularization * Chronic total occlusion * 3 vessel disease * Target lesion at distal segments or branches

Interventions

DRUGHyperemic stimuli

Hyperemic simuli of coronary flow by adenosine or nicorandil injection

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Patients who underwent coronary angiography and further hyperemic stimui

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography

Exclusion criteria

* ST elevation myocardial infarction * Cardiogenic shock * Congestive heart failure with pulmonary edema * LVEF \< 30% * Previous history of coronary revascularization * Chronic total occlusion * 3 vessel disease * Target lesion at distal segments or branches

Design outcomes

Primary

Measure	Time frame	Description
Index of microcirculatory resistance	During the procedure	derived from distal coronary pressure by transit time
TIMI frame count	Imediately after the procedure	frame count between the beginning and end of contrast column head
Coronary Clearance Frame Count	Imediately after the procedure	frame count between the beginning and end of contrast column tail

Secondary

Measure	Time frame	Description
Fractional flow reserve	During the procedure	measured by pressure wire
Coronary flow reserve	During the procedure	measured by pressure wire by thermodilution technique

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026