Healthy Subjects, Patient Performing an MRI Examination
Conditions
Brief summary
The purpose of this study is to evaluate the optimization of MRI acquisition sequences.
Interventions
OTHERMRI examination
All subjects (healthy subjects and patients) will have an MRI examination with optimized sequences
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for all subjects : * to be over 18 year-old, * to be able to understand the instructions given, * to be enrolled in a social security plan, * to have underwent a pre-inclusion medical examination, * to give a written consent. Inclusion Criteria especially for Patients : * to perform a MRI examination of the head, neck, spine, thorax, abdomen, pelvis, retroperitoneum, lower limbs, upper limbs or whole body during clinical follow-up care.
Exclusion criteria
for all subjects : * any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ), * subject under a measure of legal protection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Image quality based on standard imaging quality criteria. | 6 months after the last inclusion | The image quality will be appreciated visually at least by a radiologist or a researcher. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the Signal to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence). | 6 months after the last inclusion | Signal to Noise Ratio will be measured in arbitrary units. |
| Comparison of the Contrast to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence). | 6 months after the last inclusion | Contrast to Noise Ratio will be measured in arbitrary units. |
| Comparison of the acquisition time obtained with the optimized MRI sequence and the reference situation (standard sequence). | 6 months after the last inclusion | Time acquisition will be evaluated in minutes. |
| Comparison of blurring and artefacts obtained by the optimized MRI sequence and the reference situation (standard sequence). | 6 months after the last inclusion | Absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale. |
| Comparison of the spatial resolution obtained by the optimized MRI sequence and the reference situation (standard sequence). | 6 months after the last inclusion | Spatial resolution will be measured in mm². |
| Qualification of the MRI acquisition for a clinical study. | 6 months after the inclusion | Validation of MRI acquisition by a centralized review center. |
| Evaluation of intra-subject reproducibility on the same MRI and on two MRIs. | 6 months after the last inclusion | Measurement of intra-subject reproducibility on the same MRI and on two MRIs by the intra-class correlation coefficient for quantitative measurement or by the kappa coefficient for a qualitative measurement. |
Countries
France
Contacts
CONTACTValérie LAURENT, MD, PhD
CONTACTGabriela HOSSU, PhD
Outcome results
None listed