Sepsis, Septic Shock
Conditions
Keywords
Microcirculation, Remote ischemic conditioning, Sepsis
Brief summary
This study is an evaluation of the effect of Remote ischemic conditioning on sublingual microcirculation in patients with sepsis.
Detailed description
This prospective open-label trial is performed in mixed ICU in a tertiary teaching hospital. Investigators include patients with sepsis or septic shock within the first 24 h after ICU admission. Remote ischemic conditioning (RIC) procedure comprise three repetitions of brachial cuff inflation to 200 mmHg for five minutes following deflation to 0 mmHg for another five minutes. The procedure overall took 30 minutes. RIC is performed at inclusion and repeated 12 h and 24 h later. Sublingual microcirculatory measurements are obtained before and after each RIC procedure, using incidence dark field (IDF) device.
Interventions
PROCEDURERemote ischemic conditioning
Remote ischemic conditioning (RIC) procedure comprise three repetitions of brachial cuff inflation to 200 mmHg for five minutes following deflation to 0 mmHg for another five minutes. The procedure overall took 30 minutes.
Sponsors
Lithuanian University of Health Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with sepsis or septic shock within the first 24 h after ICU admission.
Exclusion criteria
* age \< 18 years, * pregnancy, * advanced malignancy, * peripheral artery disease affecting both arms, * oral mucosal inflammation or injury or technical difficulties in obtaining sublingual images.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular flow index (MFI) and Proportion of perfused small vessels (PPV) | 30 minutes | The differences in MFI and PPV between pre- and post-RIC performance. |
Countries
Lithuania
Outcome results
None listed