Covid19, Hormone Disturbance, Sperm Count, Low
Conditions
Keywords
COVID-19, Male infertility, Semen parameters, Sex-related hormone levels
Brief summary
Coronavirus Disease-19 (COVID-19) is a global pandemics which affects many organs and systems with a range of morbidities and high mortality rates. There are a number of studies revealed that COVID-19 may affect the testes and male genital tract which may in turn disrupt the gonadal functions.The current study aimed to evaluate the effect of COVID-19 on semen parameters and sex-related hormone levels.
Detailed description
In this current study, the investigators aimed to elucidate the alteration in semen parameters of the infertile male patients who had been infected with SARS-CoV-2, through the comparison of the spermiogram results which were reported before and after the diagnosis of COVID-19. The investigators also aimed to evaluate the impact of COVID-19 on the sex-related hormone levels as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T). The current study is conducted in Ankara City Hospital, the highest capacity tertiary health care center of the capital town of Turkey. The study included 21 patients who applied to Ankara City Hospital, Andrology Clinic for male infertility up to 05 October, 2020 and have had the semen analyses reported before and after the clinically confirmed diagnosis of COVID-19 through reverse transcriptase PCR. Besides the semen analyses, 8 of these 21 patients have also the had the reported levels of T, FSH and LH which were also analyzed.
Interventions
OTHERClinical assessment
Comparison of semen analysis results and sex-related hormone levels between the dependent groups which were defined as before COVID-19 and after COVID-19 (the data of the same patient group were compared as before and after the diagnosis of COVID-19).
Sponsors
Ankara City Hospital Bilkent
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Reproductive age Infertile men Clinically confirmed (with reverse transcriptase polymerase chain reaction-RT PCR) COVID-19 history Semen analyses performed before and after the diagnosis of COVID-19 (must be applicable for all patients) Sex-related hormone levels including FSH, LH, and T which were reported before and after the diagnosis of COVID-19 (was applicable for some of the patients)
Exclusion criteria
Azoospermia Semen analyses performed only before or after the diagnosis of COVID-19 Semen analysis performed in another hospital RT-PCR results which were reported in another hospital Chronical renal disease Chronical liver failure Patient age lower than 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Semen analyses parameters including sperm motility (total, progressive, non-progressive and immotile | first 1 hour | cell count percentage |
| Semen analyses parameters including sperm concentration | first 1 hour | cell count per milliliters of semen sample. |
| Semen analyses parameters including sperm morphology | first 1 hour | percentage of normal forms |
| Semen analyses parameters including semen volume | first 1 hour | milliliters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sex-related hormone levels including testosterone | 20 minutes | nanograms per deciliter |
| Sex-related hormone levels including follicle stimulating hormone and luteinizing hormone | 20 minutes | Units per liter |
Countries
Turkey (Türkiye)
Outcome results
None listed