Healthy
Conditions
Keywords
functional MRI, subliminal perception, EEG, neurofeedback, attention
Brief summary
Subliminal perception of visual stimuli can be studied with functional brain imaging, e.g. with functional magnetic resonance imaging (fMRI). However, it is unclear how subliminal perception affects connectivity in the brain. Further, it is not known if real-time (rt) fMRI neurofeedback of brain areas involved in subliminal perception can lead to supra-threshold perception. For attention tasks, the investigators hypothesize that functional connectivity strength is mediated by the insular cortex during both supra-threshold and subliminal perception. Additionally, the investigators hypothesize that rt-fMRI neurofeedback training should alter neuronal and behavioral responses.
Detailed description
In this project, using healthy adults, the investigators have 2 aims: 1. Apply electroencephalography (EEG) and fMRI before and after rt-fMRI neurofeedback during attention tasks to identify brain regions involved in subliminal and supraliminal perception. 2. Apply functional connectivity analyses during these tasks.
Interventions
OTHERreal-time fMRI
Brain regions can be trained, i.e. fMRI activity can be actively modulated online by humans, using rt-fMRI (Bruhl, Scherpiet et al. 2014, Bruhl 2015, Emmert, Kopel et al. 2016).
Sponsors
Swiss National Science Foundation
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults (\> 18 \< 80 years), which can read and sign the informed consent form * Male and female * Right-handed
Exclusion criteria
* metallic items in the body (i.e. eye splinter, MR incompatible implants) * pacemaker * claustrophobia * pregnant participants * participants suffering from a degenerative disorder of the Central Nervous System, such as Stroke, Multiple Sclerosis, Parkinson's Disease, Alzheimer's Disease and Huntington's Disease and with major psychiatric disorders such as schizophrenia, depression, or anxiety disorder * Drug intake (psychopharmaca)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI during supra-threshold and subliminal perception | 2020 - 2022 | — |
| rt-fMRI activity | 2020 - 2022 | rt-fMRI activity: fMRI signal changes during repetitive real time fMRI based training |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional connectivity | 2020 - 2022 | Examination of fMRI signal dependencies (coherence) between brain regions. |
| EEG activity | 2020 - 2022 | EEG activity: Event related potentials and spectral band power for different trial types |
| fMRI task performance | 2020 - 2022 | Reaction time and accuracy |
Countries
Switzerland
Outcome results
None listed