Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects

Clinical and Radiographic Evaluation of Open Flap Debridement With or Without Nanocrystalline Hydroxyapatite Bone Graft in Management of Periodontal Intrabony Defects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04643288

Enrollment

Registered

2020-11-25

Start date

2018-09-01

Completion date

2020-05-25

Last updated

2020-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Keywords

periodontal intrabony defects

Brief summary

The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis. Subjects were recruited from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University. This clinical trial was meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with open flap debridement versus open flap debridement alone in the treatment of periodontal intrabony defects.

Detailed description

periodontal intrabony defects in patients with moderate or advanced chronic periodontitis were treated with open flap debridement only in the control group while open flap debridement and Nanocrystalline Hydroxyapatite bone graft substitute was performed for the intervention group. probing pocket depth, clinical attachment level, gingival index, plaque index, gingival recession and bone defect area were assessed at baseline and six months post surgically to evaluate the possible improvement in the clinical and radiographic outcomes.

Interventions

PROCEDUREopen flap debridement

open flap debridement for managing two and three walls intrabony periodontal defects

PROCEDUREn-HA bone graft

Nanocrystalline Hydroxyapatite bone graft substitute for managing two and three walls intrabony periodontal defects

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

35 Years to 56 Years

Healthy volunteers

Inclusion criteria

* systemically healthy patients * diagnosed with moderate to advanced chronic periodontitis * periodontal defects with at least one site with probing pocket depth (PPD) ≥ 5mm, clinical attachment loss (CAL) ≥ 4mm and two or three-walled intra-bony defects ≥ 3mm * evidence of intrabony defects using periapical radiographs

Exclusion criteria

* teeth with suprabony defects or 1-wall intrabony defects * pregnant or lactating women * patients taking any medication 3 months prior to the study * patients receiving any periodontal treatment 6 months prior to study initiation * former or current smokers.

Design outcomes

Primary

Measure	Time frame	Description
change in probing pocket depth	baseline and after six months	William's graduated periodontal probe used to measure probing pocket depth from the gingival margin to the base of the sulcus

Secondary

Measure	Time frame	Description
change in clinical attachment level	baseline and after six months	William's graduated periodontal probe used to measure clinical attachment level from the cementoenamel junction to the base of the sulcus
change in the bone defect area	baseline and after six months	periodical digital radiographs using Digora software to measure the bone defect area

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026