Diabetes Mellitus, Type 2
Conditions
Brief summary
OS is an important pathogenetic mechanism for the development of T2DM and its complications. Oxidative stress is an imbalance of the generation of free radicals or known as reactive oxygen species (ROS) and reactive nitrogen species \[RNS\]) and their neutralization by the antioxidant mechanisms. Increased levels of ROS and RNS lead to damage of lipids, proteins, and DNA, ultimately causing the destruction of the islet cells of pancreas through apoptosis . Elliptical trainer device is a relatively new modality of exercise and is advertised to be superior to a treadmill because of the low joint impact and the more reasonable costs of an elliptical trainer compared to a treadmill . Additional quantative research is needed to further evaluate the effectiveness of elliptical trainers and the physiological and perceptual responses to the machine Electroacupuncture (EA) is a treatment form of traditional acupuncture in which small electrical currents are passed through needles inserted into the subject's skin using EA stimulator. It seems to have more acceptable results and effects on many important clinical applications and medical research sets .
Detailed description
60 diabetic patients will be randomly divided to electroacupucture group (30 patients) and high intensity elliptical training (30 patients). the treatment will be done for 5 sessions per week for 12 weeks
Interventions
DEVICEhigh intensity elliptical training
30 patients will receive 30 minutes of high intensity interval training on elliptical trainer, 5 times per week, for 12 week
DEVICEelectrocaupuncture
30 patients will receive 30 minutes of electroacupuncture on bilateral PC 4 and PC 6 for 5 times per week, for 12 week
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* type 2 diabetic elderly * Body mass index less than 30 kg/m2. * Fasting blood more than 126 mg/dl
Exclusion criteria
* cardiac patients * renal patients * respiratory patients * liver patients * patients who received any complementary therapies within 3 past months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| superoxide dismutase | It will be measured after 12 weeks | marker of anti-oxidative stress |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| nitric oxide | It will be measured after 12 weeks | will be measured in plasma |
| lipid hydroperoxidase | It will be measured after 12-week training | will be measured in plasma |
Countries
Egypt
Contacts
Primary ContactAli Ismail, lecturer
Outcome results
None listed