Gastroesophageal Varices, Liver Cirrhosis, Variceal Hemorrhage
Conditions
Keywords
Elasticity Imaging Techniques, Ultrasound
Brief summary
Through the parameters of liver stiffness and spleen stiffness obtained by combi-elastography technique, summarize and analyze the warning index of esophagogastric variceal bleeding in patients with cirrhosis, so as to provide a new and valuable technique for clinical diagnosis.
Detailed description
Firstly,the combi-elastography technique developed by HITACHI uses the method of multi-index and multi-parameter to evaluate the liver stiffness and spleen stiffness comprehensively. And then,this prospective study is designed to follow up patients with cirrhosis for a period of 12 months, summarize and analyze the warning index of bleeding in patients with cirrhosis,so as to provide a new and valuable technique for clinical diagnosis.
Interventions
None listed
Sponsors
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 18-80 years old, no gender limit; * The clinical diagnosis is in line with patients with liver cirrhosis caused by chronic hepatitis B, and the gastroscopy is in line with the indications of portal hypertension; * Gastroscopy needs to provide the degree of gastroesophageal varices; * Sign the informed consent form.
Exclusion criteria
* Patients with cirrhosis and portal hypertension because of other causes or combined with other causes(such as viral hepatitis other than hepatitis B,Autoimmune liver disease, alcoholic liver disease, metabolism-related fatty liver disease, etc.) * Patients with a history of spleen-related operations, such as splenectomy, splenic embolism; * Patients undergoing portosystemic shunt or TIPS; * Isolated esophageal venous tumor and its bleeding patients; * History of upper gastrointestinal tumor or bleeding from gastric ulcer , etc; * Those with serious diseases of other systems that cannot cooperate with elastography examination, such as heart failure, renal failure, mental illness, etc; * Ascites before liver and spleen result unable to complete elasticity examination; * Pregnant patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| F index | baseline | F index is linked to the degree of liver fibrosis,and it can be available by ultrasound elastography checking. |
| A index | baseline | A index is linked to the degree of hepatitis ,and it can be available by ultrasound elastography checking. |
| Spleen stiffness | baseline | Spleen stiffness can be available by ultrasound elastography checking. |
Countries
China
Contacts
Primary ContactJie Yu, Doctor
Outcome results
None listed