Alcohol Use Disorder (AUD)
Conditions
Keywords
Alcohol Use Disorder, Cognitive Rehabilitation, Virtual Reality, Paper-and-Pencil Tasks
Brief summary
Cognitive dysfunction is one of the different consequences of excessive alcohol consumption, affecting many domains associated with prefrontal and temporal lobes, such as attention, verbal fluency, and memory. This study will explore the clinical impact of two cognitive rehabilitation tools to promote cognitive improvements of AUD individuals.
Detailed description
Excessive consumption of alcohol affects many functions associated with the prefrontal and temporal lobes, including different executive functions, memory, and complex motor control. Among several treatments, the Transtheoretical Model, a multidisciplinary approach, is one of the most standardized. However, it lacks effective and innovative cognitive rehabilitation tools. In this study, two cognitive rehabilitation tools, already clinically validated for stroke patients, will be implemented to promote cognitive recovery of Alcohol Use Disorder (AUD) individuals under treatment in the Alcoholic Rehabilitation Center S. Ricardo Pampuri from Casa de Saúde S. João de Deus (Madeira, Portugal). Within a randomized controlled trial with 60 participants, this study intend to assess and compare the clinical effectiveness of both a paper-and-pencil tasks training and content equivalent virtual reality (VR) simulation of activities of daily living with time-matched standard treatment.
Interventions
PROCEDUREVirtual Reality
The Virtual Reality group will be involved in the Standard treatment protocol and will perform personalized activities of daily living in a virtual city environment (Reh@City).
PROCEDUREPaper and Pencil
The paper and Pencil group will be involved in the Standard treatment protocol and will perform personalized cognitive paper-and-pencil tasks, using the Task Generator tool.
PROCEDUREControl Group
The standard treatment protocol.
Sponsors
Instituto São João de Deus
Universidade da Madeira
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Inpatients of Centro de Alcoologia Ricardo Pampuri (with Alcohol use Disorder diagnosis) * Education (able to read and write) * Standard neuropharmacological protocol
Exclusion criteria
* Abuse of other substances * Neurological and psychiatric pathology (present or past) * Severe depressive symptoms as assessed by the Beck Depression Inventory * Visual problems that can affect the performance of the tasks (hemianopsy, diplopia)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Montreal Cognitive Assessment (Cognitive Screening). | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up | Change from baseline in the Montreal Cognitive Assessment |
| Frontal Assessment Battery (FAB- Executive functioning). | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up | Change from baseline in the Frontal Assessment Battery. |
| SF-36 Medical Outcomes Study 36 - Item Short - Form Health Survey | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up | Change from baseline in the SF-36 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symbol Search and Coding (WAIS III). | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up] | Change from baseline in the Symbol Search and Coding (WAIS III) |
| Toulouse-Pieron (Attention). | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up | Change from baseline in the Toulouse-Pieron Cancellation Test. |
| Letter-number sequencing (WAIS-III)- Working Memory | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up] | Change from baseline in the Letter-number sequencing (WAIS III) |
| Verbal Paired Associates (WMS-III) (Memory). | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up | Change from baseline in the Verbal Paired Associates (WMS-III) |
| Rey Complex Figure (Visuospatial skills and visual memory). | Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up | Change from baseline in the Rey Complex Figure. |
Countries
Portugal
Outcome results
None listed