ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04639856

Enrollment

Registered

2020-11-23

Start date

2018-07-15

Completion date

2019-01-15

Last updated

2020-11-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Revascularization

Keywords

Coronary Artery Bypass Grafting

Brief summary

Coronary artery bypass graft (CABG) surgery can result in severe postoperative complications, such as renal and pulmonary failure. In about 80% of the cases worldwide, it is currently performed with cardiopulmonary bypass (CPB) with cardiac arrest. Cardiopulmonary bypass leads to a systemic inflammatory response, which may be induced by the contact of circulating blood with artificial surfaces of the extracorporeal circuit.\[1\] To reduce postoperative complications caused by systemic inflammation, off-pump CABG was reintroduced into clinical practice in the early 1990s. During off-pump surgery, the coronary artery grafts are placed on coronaries of a beating heart, thereby avoiding aortic cross clamping and CPB. \[1\] There are many studies and debates about the two approaches to cardiac revascularization via CABG. This study aims to answer the question as to difference in the ICU stay of patients with low ejection fraction undergoing cardiac revascularization bet ween off pump and on pump coronary artery bypass grafting and better treatment option shall be adopted in future.

Interventions

PROCEDURECoronary Artery Bypass Grafting

on-pump vs off pump Coronary artery Bypass Grafting

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

* All patients of either gender between the ages of 40 to 80 * Ejection fraction of less than or equal to 35% undergoing CABG. * undergoing CABG.

Exclusion criteria

* Patients with ejection fraction of more than 35% * Patients with previous history of cardiac revascularization * Patients with previous history of chronic kidney disease and obstructive sleep apnea.

Design outcomes

Primary

Measure	Time frame	Description
ICU Stay	6 Months	post operative ICU stay in patients undergoing cardiac revascularization

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026