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Responses to Information on Treatments for Depression

Responses to Information on Treatments for Depression

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04639765
Enrollment
300
Registered
2020-11-20
Start date
2020-10-28
Completion date
2020-12-30
Last updated
2021-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive Symptoms

Keywords

depression, treatment preference, treatment information

Brief summary

The purpose of this study is to determine the impact of different messages about depression treatments.

Detailed description

Participants recruited through Amazon Mechanical Turk (MTurk) will complete a screening questionnaire and provided the opportunity to consent to participate. Upon entry to the study, eligible participants will complete several questionnaires pre- and post-randomization. Randomization will be to view either a video detailing a type of depression treatment (cognitive behavioral therapy, antidepressant medication, or the combination of both treatments) with and without an emphasis on personalization. A no video condition is also included.

Interventions

OTHERCBT without Personalization

Intervention involves a video describing CBT without a message about personalization.

OTHERCBT with Personalization

Intervention involves a video describing CBT with a message about personalization.

OTHERADM without Personalization

Intervention involves a video describing antidepressant medication without a message about personalization.

OTHERADM with Personalization

Intervention involves a video describing antidepressant medication with a message about personalization.

OTHERCombined Treatment without Personalization

Intervention involves a video describing the combination of cognitive behavior therapy and antidepressant medication without a message about personalization.

OTHERCombined Treatment with Personalization

Intervention involves a video describing the combination of cognitive behavior therapy and antidepressant medication with a message about personalization.

Sponsors

Ohio State University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* PHQ-9 Score indicating a history of elevated depression symptoms * A high MTurk completion rate * Must pass all attention checks inserted into the questionnaires * No history of treatment for depression

Exclusion criteria

* none

Design outcomes

Primary

MeasureTime frameDescription
Regressed change from baseline in expectations on the Credibility/Expectancy Questionnaire (CEQ)Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)The CEQ is a validated, commonly used measure assessing views of the credibility and expectations for benefit from a treatment.
Regressed change from baseline in prognostic pessimism on an adapted version of the Perceptions of Depression Scale (PDS)Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)Measured using an adapted version of the PDS, a validated scale measuring general prognostic pessimism. Minor changes to wording were made to directly address the three different interventions in the study (CBT, ADM, Combined Treatment).

Secondary

MeasureTime frameDescription
Regressed change from baseline in personal and perceived depression stigma on the Depression Stigma Scale (DSS).Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)The DSS is a valid and reliable measure for assessing personal and perceived stigma related to depression. The scale contains two subscales: personal stigma and perceived stigma.
Regressed change from baseline in affect on the Positive and Negative Affectivity Scale (PANAS)Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)The PANAS is a widely used measure for positive and negative affect, and has been shown to be valid and reliable.
Willingness to take a next step.Up to 90 minutes to complete assessment. Assessed at the end of the study questionnaires (same day)Participants are given the option to learn more about finding cognitive behavioral therapy, antidepressant medications, or combination therapy. Based on their responses, they are provided links to relevant websites. This approach has been adopted from traditional marketing research to assess participants' responsiveness to a message.
Regressed change from baseline in beliefs on the etiology of depression on the Reasons for Depression Questionnaire (RFD).Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)The RFD is a valid and reliable measure for assessing one's beliefs on the etiology of depression.
Regressed Change from baseline on the Beck Hopelessness Scale (BHS)Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)The BHS is the most widely used measure for hopelessness, and has been shown to be valid and reliable.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026