Breast Cancer
Conditions
Brief summary
This is a transversal monocentric study comparing two groups of women (group 1, patient group : patients who have been treated for a breast cancer with taxane-based chemotherapy ; group 2, control group : healthy volunteers). The aim of this study is to evaluate if a difference exists regarding the maximal isometric muscle strength between group 1 and 2.
Detailed description
All subjects will be evaluated a single time during two hours. For patients from group 1 the evaluation should take place within the two weeks that follow the end of adjuvant treatment. There is no specificity regarding evaluation of volunteers from group 2, their evaluation can take place at any time.
Interventions
OTHERCharacterization of Neuromuscular Function and Fatigue
at inclusion
Sponsors
UR 3072 - Mitochondrie, Stress oxydant et Protection musculaire
Institut de cancérologie Strasbourg Europe
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
: Group 1 - Patients : * Give written inform consent * Age ≥ 18 years * Affiliate to social security system * Ability to speak, understand and read French * Breast cancer, Stage II or III, treated by taxane-based chemotherapy Group 2 - Control group : * Give written inform consent * Age ≥ 18 years * Affiliate to social security system * Ability to speak, understand and read French
Exclusion criteria
Group 1 - Patients : * \< 18 years old or patients ≥ 18 years old under guardianship, or supervision * Psychiatric, musculoskeletal or neurologic disorders * Patients presenting one of the following contraindications to transcranial magnetic stimulation : * Presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.) * History of epilepsy * Brain injury (vascular, traumatic, tumour-induced, infectious or metabolic) * Women that are pregnant * Serious or recent heart disease Group 2 -Control group : * \< 18 years old or patients ≥ 18 years old under guardianship, or supervision * Psychiatric, musculoskeletal or neurologic disorders * Pacemaker implantation * History of cancer * All known chronic disease * Subjects presenting one of the following contraindications to transcranial magnetic stimulation : * Presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.) * History of epilepsy * Brain injury (vascular, traumatic, tumour-induced, infectious or metabolic) * Women that are pregnant * Serious or recent heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal isometric muscle strength for knee extensors | At Inclusion | Measured with force sensors. Significant differences between the two groups will be assessed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with neuromuscular fatigue | At Inclusion | Assessment using surface electromyography. Significant differences between the two groups will be assessed. |
| Number of Participants with subjective fatigue. | At Inclusion | Questionnaire Functional Assessment of Chronic Illness Therapy - Fatigue Scale (FACIT-F) version 4. Significant differences between the two groups will be assessed. |
| Number of Participants with muscle architecture. | At Inclusion | Assessment using muscle ultrasonography. Significant differences between the two groups will be assessed. |
| Number of Participants with body composition. | At Inclusion | Assessment using bio-impedance analysis. Significant differences between the two groups will be assessed. |
Countries
France
Outcome results
None listed