AMH, Infertility
Conditions
Brief summary
In China, the incidence of infertility is about 15%, and patients need to use assisted reproductive technology (ART) to obtain pregnancy. It is particularly important to accurately predict the patient's ovarian response before initiating controlled ovulation hyperstimulation (COH). At present, the commonly used AMH detection method is enzyme-linked immunoassay (ELISA), and it has obtained the normal reference range for ovarian response. In recent years, with the development of detection technology, chemiluminescence immunoassay（CLIA） detection reagents have been successively used for the detection of AMH. However, there are few studies on the comparison of these two detection methods. The predictive value of the new method on ovarian response was lack. Therefore, by comparing the two methods of ELISA and CLIA detection of AMH levels in this study, the predictive value of poor ovarian response (the number of retrieved oocyte ≤ 3) and high response (the number of retrieved oocyte ≥ 15) in IVF/ICSI stimulation cycle was analyzed. In order to provide more reference basis for individualized COH, the AMH cutoff value of low and high ovarian response by the new method predicts was analyzed. At the same time, the prediction value of the two methods is compared to determine whether the new CLIA is suitable for clinical application.
Interventions
DIAGNOSTIC_TESTELISA
ELISA kit detecting the serum AMH level
DIAGNOSTIC_TESTChemiluminescence
CLIA method detecting the serum AMH level
Sponsors
Reproductive & Genetic Hospital of CITIC-Xiangya
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Inclusion criteria
* The first IVF/ICSI COH cycle; * the causes of infertility :fallopian tube factors and/or male factors;
Exclusion criteria
* Endometriosis; * PCOS; * Adenomyosis; * PGT cycle because of the female chromosome abnormality or genetic abnormality; * FET cycle; * Malignant tumor patient.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the AMH（CLIA） cutoff value of low and high ovarian response | the day of oocytes retrieved，about three months after AMH test | the poor ovarian response :the number of retrieved oocyte ≤ 3,the high ovarian response :the number of retrieved oocyte ≥ 15 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of oocytes retrieved | 34-36 hours after hCG trigger，about three months after AMH test | the number of oocytes retrieved after hCG trigger |
| the serum AMH level | any day of the menstrual cycle, about three months after study starting | anti-muller hormone |
Countries
China
Outcome results
None listed