Obese, Pregnancy Related, Vascular Diseases, Visceral Obesity
Conditions
Brief summary
Brachial artery flow-mediated in obese and normal-weight pregnant women dilation of uterine artery doppler and umbilical artery doppler results comparison of
Detailed description
The systemic inflammatory effect caused by obesity and vascular disorder It has been reported that it creates studies. Healthy Vascular Endothelial structure increases vascular tone by regulating nitric oxide (NO) release. Reduced nitric oxide production, reducing flexibility It has a facilitating effect on hypertensive diseases and other obstetric diseases. Endothelial function, which is a non-invasive, easily applicable, and reproducible method It can be detected by endothelium-dependent vasodilation. A good indicator of endothelial function in studies in which the brachial artery flow-mediated dilation (FMD) shown. Brachial artery blood pressure cuff at forearm level in normal healthy people with compression for 3-5 minutes 50 mmHg above systolic pressure, 60-120 seconds after loosening the cuff When measured later, individuals with healthy endovascular function and the brachial artery are also reactive hyperemia, and a 10% dilatation is expected. Many obstetric effects such as obesity preeclampsia, preterm labor, gestational diabetes, preterm labor Although it was found to be related to pathology, the relationship between them could not be determined exactly. Our study aimed to increase brachial artery dilatation in obese and normal pregnant women. By comparing, determine the level of nitric oxide and endovascular function. Also uterine Vascular structures of obesity by comparing vascular structures with artery and umbilical uterine dops examine the effect on Pregnant women between the ages of 18-40 who apply to the Diseases and Obstetrics outpatient clinic will be taken. 24-28. Brachial artery dilatation, uterine, and umbilical artery doppler between 11-14, 37-40w weeks between gestational weeks, and visceral adipose tissue measurement at first trimester will be examined.
Interventions
OTHERultrasonography
vascular and adipose tissue measurement by ultrasonography
Sponsors
Diyarbakir Women's and Children's Diseases Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Inclusion criteria
* obese and normal pregnant * 11-14 weeks * 24-28 weeks * 37-40 weeks
Exclusion criteria
* smoking * chronic vascular disease * Diabetes mellitus * Over 40 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To define the relationship between obesity and endovascular dysfunction by brachial artery dilatation method. | 3 month | To examine the possible effects of obesity on the endovascular system with the brachial artery dilation method. |
| Measurement of uterine artery doppler in obese and normal pregnant women | 3 month | To determine whether obesity has an effect on uterine artery resistance. |
| Measurement of obese and normal pregnant umbilical artery doppler | 3 month | trying to understand whether obesity has fetal effects by examining umbilical artery doppler in obese pregnants and normal pregnants, |
| First trimester visceral adipose tissue and brachial artery measurement | 3 month | By measuring the amount of visceral tissue in the first trimester obese and normal pregnant women with Armellini method; Investigation of its effects on endovascular dysfunction through brachial artery dilatation |
Countries
Turkey (Türkiye)
Outcome results
None listed