Infection Viral
Conditions
Brief summary
There are still uncertainties about the existence of protective immunity and the duration of protective antibodies in patients infected with SARS-CoV-2. Serological testing is an appropriate tool for epidemiological investigations to assess the persistence of antibodies over time. The nature of the immune response induced by this virus is also poorly understood. This ancillary study aims at assessing the immunological characteristics of patients that participated in the NOSO-COR study at Hospices Civils de Lyon six and twelve months after the initial infectious episode. Two visits will be scheduled at 6 and 12 months (± 1 month) after the initial SARS-CoV-2 infectious episode, Blood, saliva and nasopharyngeal samples will be collected for seroprevalence and immunological investigation.
Interventions
OTHERCollection of blood, salivary and nasopharyngeal samples.
Each visit M6 and M12 * Blood: 1 PAXgene tube (2.5mL) 1 EDTA tube (4mL), 1 dry tube with gel (5mL), 3 EDTA tubes (10mL each) * Salivary sample * Nasopharyngeal sample
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
SARS-CoV-2 confirmed by RT-PCR * Adults \> 18 years * Signed consent form * Affiliated to the French health system
Exclusion criteria
* Pregnant women * Hospitalized patients * Individuals subject to legal protection * Imprisoned individuals * Individuals who have expressed an opposition to participate, or who do not wish to donate blood samples
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Seroprevalence of SARS-CoV-2 antibodies in laboratory confirmed SARS-CoV-2 patients | Month 6 | To describe the immune response to SARS-CoV-2 infection by measuring the level of IgG and IgM in the blood of patients six months after laboratory-confirmed diagnosis of SARS-CoV-2 |
Countries
France
Outcome results
None listed