Infection in Solid Organ Transplant Recipients
Conditions
Brief summary
2.1. Study Objectives * Primary Objective(s) * Identify the incidence and risk of CDI within one year after kidney, liver, and/or pancreas transplant * Secondary Objective(s) * Identify the risk factors for recurrent CDI post-transplant in patients who were diagnosed with a CDI within one year prior to Solid Organ Transplant * Evaluate the impact of CDI on graft survival following Solid Organ Transplant
Detailed description
* Single center, retrospective cohort chart review study design * Data will be collected on all liver, kidney, pancreas and combined transplant recipients who received their graft(s) from April 1, 2015 to July 31, 2018 * Will analyze outcomes from April 1, 2014 to July 31, 2019 * Patient list will be generated in Epic and Meditech * All data will be obtained from Epic and Meditech * All data will be collected retrospectively after the patient is discharged from the hospital
Interventions
PROCEDURESolid organ transplant
Data will be collected on all liver, kidney, pancreas and combined transplant recipients who received their graft(s) from April 1, 2015 to July 31, 2018
Sponsors
Methodist Health System
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Solid organ transplant patients who received graft(s) at MDMC from April 1, 2015 to July 31, 2018 * Age \>18 years old
Exclusion criteria
* Age \<18 years old * Loss to early death defined as within one week from transplantation * Patients whose primary address is in Puerto Rico
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of C. Difficile infection (CDI) within one year post-transplant | April 1, 2014 to July 31, 2019 | Incidence of C. Difficile infection within one year post-transplant for CDI post-transplant. |
| Risk factors for CDI post-transplant - No.1 | April 1, 2014 to July 31, 2019 | Risk factors transplanted organ |
| Risk factors for CDI post-transplant - No.2 | April 1, 2014 to July 31, 2019 | Origin of transplanted graft including age of donor |
| Risk factors for CDI post-transplant No.-3 | April 1, 2014 to July 31, 2019 | Induction agent used |
| Risk factors for CDI post-transplant No.4 | April 1, 2014 to July 31, 2019 | Acid suppression |
| Risk factors for CDI post-transplant No.5 | April 1, 2014 to July 31, 2019 | First time SOT recipient |
| Risk factors for CDI post-transplant No.6 | April 1, 2014 to July 31, 2019 | History of CDI in the year prior to transplant |
| Risk factors for CDI post-transplant No.7 | April 1, 2014 to July 31, 2019 | Co-infection with HIV/AIDS |
| Risk factors for CDI post-transplant No.8 | April 1, 2014 to July 31, 2019 | Length of hospital stay |
| Risk factors for CDI post-transplant No. 9 | April 1, 2014 to July 31, 2019 | Length of intensive care unit stay |
| Risk factors for CDI post-transplant No.10 | April 1, 2014 to July 31, 2019 | Intra-operative administration of blood products |
| Risk factors for CDI post-transplant No. 11 | April 1, 2014 to July 31, 2019 | Antibiotic use in the 90 days prior to infection |
| Risk factors for CDI post-transplant No. 12 | April 1, 2014 to July 31, 2019 | Antibiotic use in the 90 days post-transplant |
| Risk factors for CDI post-transplant No, 13 | April 1, 2014 to July 31, 2019 | Hospitalization in the 90 days prior to transplantation |
| Risk factors for CDI post-transplant No, 14 | April 1, 2014 to July 31, 2019 | Hospitalization in the 90 days post-transplant |
Countries
United States
Outcome results
None listed