Cognitive Decline, Cognitive Impairment, Frontal Meningioma, Meningioma, Post-Surgical Cognition, Skull Base Meningioma, Temporal Meningioma
Conditions
Brief summary
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
Detailed description
This study will look at patients who are undergoing resection of a skull based meningioma, located in the frontal or temporal lobe, via craniotomy or via endoscopic endonasal approach. The study will compare cognitive function at baseline, at six weeks postoperatively and at one year postoperatively. The cognitive testing being done at baseline will be a clinical care set of assessments done by the speech language pathology team and will include the RBANS tests, the MoCA, PROMIS-29, and NeuroQOL-Cognitive Functions.
Interventions
OTHERLong-term Cognitive testing
These patients will undergo their standard of care cognitive testing at baseline, six weeks post-operatively and one year post-operatively.
Sponsors
Ohio State University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Inclusion criteria
* Subject has a meningioma associated with the frontal or temporal lobes * Subject is scheduled to undergo open craniotomy or Endoscopic Endonasal surgery * Subject is 18 years of age or older * The subject must in the investigator's opinion, be psychosocially, mentally, and physically able to fully comply with this protocol including the required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent * Previous surgery will not exclude the patient as a new baseline cognitive evaluation will occur.
Exclusion criteria
* Patient is a prisoner * Patient is 90 years of age or older * Pregnant women * Previous radiation to the brain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall cognitive function | 12 months | Cognitive function will be compared at baseline and at one year post-operatively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function based on surgical approach using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | 12 months | Patients divided by approach and overall cognitive function will be evaluated. |
| Cognitive function based on tumor location using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | 12 months | Patients will be divided by tumor location and cognitive function will be evaluated. |
Countries
United States
Contacts
CONTACTEmma Kurtz, BS
CONTACTUchechi Okafor, BS
PRINCIPAL_INVESTIGATORDaniel Prevedello, MD
Ohio State University
Outcome results
None listed