Fatigue, Stroke
Conditions
Brief summary
This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.
Interventions
DEVICEAnodal tDCS
40 minutes of 2mA intensity direct current stimulation was delivered over both the right and left motor cortex simultaneously
DEVICEsham tDCS
The stimulator was switched off after 2 minutes of stimulation.
Sponsors
University College, London
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Diagnosed with stroke at least 3 months post-stroke
Exclusion criteria
Other neurological conditions on Anti-depressants severe motor impairment (affected hand grip \<60% unaffected hand) severe cognitive impairment (unable to follow instructions, or give informed consent) scored \>11 in the depression sub-section of HADS questionnaire contraindications for TMS or tES
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fatigue Severity Scale - 7 | 2 weeks | a questionnaire based fatigue scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting Motor Threshold | 1 day | This is a measure of cortical excitability as measured by transcranial magnetic stimulation |
| Input-output curves | 1 day | This is a measure of cortical recruitment as measured by transcranial magnetic stimulation |
| Perceived effort - Explicit | 1 day | A VAS scale associated with a grip task |
| Perceived effort - Implicit | 1 day | A novel line length estimation task |
Countries
United Kingdom
Outcome results
None listed