CSC, Lung Cancer, Nonsmall Cell, Relapse/Recurrence
Conditions
Keywords
Non Small Cell Lung Cancer, Cancer Stem Cells
Brief summary
The present study is a prospective cohort study. The aim is to assess the relationship between the presence of cancer stem-cells (CSC) and the risk of relapse in patients with early and locally advanced adenocarcinoma and squamous cell carcinoma of the lung
Interventions
GENETICExposure to lung cancer stem cells
The exposure to lung cancer stem cells was measure as the percentage of Aldehyde dehydrogenase (ALDH) on all viable cells extracted from surgically resected tumor specimens
Sponsors
Beatrice Aramini
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* patients with stage I, II or IIIA adenocarcinoma of squamous cell carcinoma of the lung * age between 18 and 85 * R0 resection * availability of formalin-fixed, paraffin-embedded surgery specimen from the primary tumor * availability of fresh surgical specimen for cytofluorimetric analysis
Exclusion criteria
* incomplete resection * unknown tumor, node or metastasis status * synchronous tumors * previous lung cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relapse Free Survival | Minimum follow-up time: 1 year | Days from lung cancer resection to relapse |
Countries
Italy
Outcome results
None listed