Respiratory Compliance
Conditions
Brief summary
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures. Then determine the most appropriate combination of positive end-tidal pressure and tidal volume.
Interventions
OTHERChanges in positive end-expiratory pressure and tidal volume
When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order. Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg
Sponsors
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 6 Years
Healthy volunteers
No
Inclusion criteria
* Children undergoing surgery \> 1 hour under general anesthesia * Children ≤ 6 years * American society of anesthesiology physical status I, II
Exclusion criteria
* Previous lung surgery * Bronchopulmonary dysplasia, respiratory distress syndrome * Other interstitial lung disease * Laparoscopic surgery * Thoracic surgery, abdominal surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intratidal compliance profiles in each ventilator settings | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) | The investigators will determine Intratidal compliance profile using the changes in compliance over time --\> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory compliance | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) | ml cmH2O-1 |
| Driving pressure | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) | cmH2O |
| Blood pressure | During general anesthesia (up to about 50 min-1 hr after induction of anesthesia) | mmHg |
Countries
South Korea
Outcome results
None listed