Inflammatory Response
Conditions
Brief summary
undertake confidently both open and laparoscopic cholecystectomy. Major types of body injuries surgical or accidental; evoke a temporary, yet predictable systemic inflammatory response caused by hormonal, immunological and metabolic mediators. This inflammatory response is essential for tissue repair and has evolved to maximize the organisms' healing potential. In healthy individuals the inflammatory response to major surgery is well balanced consisting of pro- and anti-inflammatory mediators. The severity of injury, the occurrence of surgical complications and its accompanying level of stress may hinder the balance of the inflammatory response6.
Interventions
DRUGMorphine Sulfate
intrathecal morphine will be added to anaesthetics
DRUGmorphine+lidocaine
local anesthetic will be infused intravenously
DRUGSaline
intravenous saline infusion
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients aging 18 - 55 years old * Patients scheduled for abdominal surgeries * Patients with American Society of Anesthesiologists (ASA) I, II physical status
Exclusion criteria
* Patients' refusal. * Critically ill patients. * Patients who have contraindications to regional anesthesia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual analogue score | 24 hours | a scale to measure pain intensity graded from 0 = no pain to 10 = worst pain |
Countries
Egypt
Outcome results
None listed