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Physical Therapy for Liver Cirrhosis

Neuromuscular Electric Stimulation and Exercises Effect on Functional Exercise Performance and Quality of Life in Cases of Liver Cirrhosis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04629456
Enrollment
60
Registered
2020-11-16
Start date
2020-01-07
Completion date
2020-06-05
Last updated
2020-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cirrhosis, Biliary

Keywords

liver cirrhosis, exercises, neuromuscular electric stimulation, exercise capacity, quality of life

Brief summary

Patients with liver cirrhosis have severe physical deconditioning. Aim: To compare between the effect of neuromuscular electric stimulation(NMES) and exercises (EX)on treatment of patients with liver cirrhosis.

Detailed description

70 patients have been chosen from department of internal medicine, Cairo university hospitals, Egypt. 5 patients refused to participate .65 patients divided randomly into 2 groups. All the procedures were explained to patients.2 patients refused to sign informed consent and excluded from the study. 31 patients in group1 and 32 patients in group2. 1patients dropped in group1 and excluded from the study and two patients didn't continued the programmed treatment in group 2 and their data removed. Thirty patients in each group signed an informed consent and complete the treatment program.

Interventions

A total of eight electrodes were placed on the quadriceps femoris muscles (four on each leg): two on the vastus medialis, one on the rectus femoris muscle, and one on the vastus lateralis muscle. The stimulation protocol of the NMES consisted of a symmetrical biphasic square pulse at 75 Hz, a duty cycle of 6 seconds (sec.) on and 29 sec. off, a pulse time of 410 sec. during a session lasting 20 min. The intensity was increased to maximum individual toleration. The muscle contractions were visible and palpable.

OTHERExercises

The chair-seated exercises were used in the early stages of the program because the participants were frail adults. Repetitions of toe raises, heel raises, knee lifts, knee extensions, and others were performed while seated on a chair. Hip flexions, lateral leg raises, and repetitions of other exercises were performed standing upright behind the chair and holding the back of the chair for stability. To strengthen lower extremities, a fixed weight was placed on the ankle while participants performed strengthening exercises. Weights of 0.50, 0.75, 1.00, and 1.50 kg were used in accordance with each participant's strength level as the resistance progressively increased. The exercises performed using these ankle weights included seated knee flexion and extension and standing knee flexion and extensions. Exercises using a resistance band: Resistance bands were used to strengthen lower body. Lower body exercises included leg extension and hip flexion

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
35 Years to 59 Years
Healthy volunteers
No

Inclusion criteria

* Positive for anti-HCV. * Not under antiviral therapy at entry. * Positive for chronic hepatitis or compensated cirrhosis. * Negative for hepatitis B surface (HBs) antigen. * Free of co-infection with HIV. * Not pregnant. * Systolic blood pressure of less than 180 mmHg or diastolic blood pressure of less than 110 mmHg. * (viii)No ischemic heart disease or severe arrhythmia

Exclusion criteria

* Significant cardiac disease (ejection fraction \<60% or history of coronary artery disease). * Chronic renal failure on dialysis. * Hemoglobin \<11.0 g/L. * Human immunodeficiency virus infection. * Hepatocellular carcinoma. * Active non-hepatocellular carcinoma related malignancy. * Myopathy. * Any physical impairment or orthopedic abnormality preventing EX, or post-liver transplantation

Design outcomes

Primary

MeasureTime frameDescription
Sitting standing test12 weeknumber of cycle /30 seconds
Balance12 weeksSeconds
Time up and go test12 weeksnumber of cycle / minute
6 Minutes walk distance12 weeksdistance walked in 6 minutes
2 Minutes steps test12 weeksnumber of steps in 2 minutes.
Chronic liver diseases questionnaire (CLDQ)12 weekscore
SF-3612 weekScore

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026