Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity

Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity During Arthroscopic Rotator Cuff Repair: A Randomized Double-Blind Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04628676

Enrollment

100

Registered

2020-11-13

Start date

2017-02-01

Completion date

2020-01-30

Last updated

2020-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rotator Cuff Tears

Keywords

shoulder arthroscopy, irrigation, epinephrine, image quality, tranexamic acid, cuff tear repair, visual clarity

Brief summary

The primary aim of this report is to determine whether there is a difference between Epinephrine and Tranexamic acid in providing visual clarity during arthroscopic rotator cuff tear repair.

Interventions

DRUGtranexamic acid

Tranexamic acid is added to the irrigation fluid used in arthroscopic shoulder surgery.

DRUGEpinephrine

Epinephrine is added to the irrigation fluid used in arthroscopic shoulder surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* • Age \> 18 years * American Society of Anesthesiologist Physical Status Classification System : 1-2 * Undergoing a full arthroscopic double-row repair due to full-thickness cuff tear * Being willing to participate the study

Exclusion criteria

* • Age \< 18 years * American Society of Anesthesiologist Physical Status Classification System ≥3 * Concomitant cardiac diseases * Concomitant bleeding disorder or coagulopathy * Diabetes mellitus * Being pregnant * Use of contraceptive pills * A history of previous shoulder surgery * Uncontrolled hypertension during the operation (\>180/110 mm Hg) * Unrepairable rotator cuff tears * Being unwilling to participate the study

Design outcomes

Primary

Measure	Time frame	Description
Visual analog scale	through study completion, an average of 2 year	Visual analog scale will be rated by surgeon. While 0 is the worst score with no clear vision, 10 was noted as the best score for visual clarity.

Secondary

Measure	Time frame	Description
total operating time	through study completion, an average of 2 year	period in minutes from the time the arthroscope was inserted into the glenohumeral joint until the termination of the arthroscopic procedure
average mean arterial pressure	through study completion, an average of 2 year	mean arterial pressure per operation.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026