Anesthesia, Intravenous Anesthetic Toxicity
Conditions
Keywords
Dexmedetomidine, Ketamine, Perioperative effects
Brief summary
This randomized double-blind study aimed to compare the effects of dexmedetomidine and ketamine on hemodynamic parameters, recovery criteria, and opioid consumption and advers effects in septorhinoplasty operations. Totally 63 patients were included. The groups were compared in terms of hemodynamic values, recovery times, postoperative agitation, sedation, activity, modified Aldrete and pain scores, side-effects and additional analgesia requirements at postoperative 24h.
Detailed description
A total of 63 patients 18-55 years undergoing septorhinoplasty, who were graded as American Society of Anesthesiologists physical status were randomly allocated into three groups, receiving dexmedetomidine (n=21, Group D), ketamine (n=21, Group K) and saline solution (n=21, Group S). Anesthesia was induced with propofol, cisatracurium and fentanyl. Maintenance anesthesia was done with 2-2.5% sevoflurane mixture, 50-60% oxygen and N2O. The groups were compared in terms of hemodynamic values, recovery times, postoperative agitation, sedation, activity, modified Aldrete and pain scores, side-effects and additional analgesia requirements at postoperative 24h.
Interventions
DRUGDexmedetomidine
dexmedetomidine was administered as a gradual bolus of 1 µg/kg/10ml 10 min before induction of anesthesia and then as an infusion of 0.4 µg/kg per min (30 ml/h). In Group K, ketamine was administered as a 0.4 mg/kg/10ml IV bolus 10 min before induction of anesthesia and in the form of 10 µg/kg per min infusion after induction (30 ml/h).
DRUGKetamine
In Group K, ketamine was administered as a 0.4 mg/kg/10ml IV bolus 10 min before induction of anesthesia and in the form of 10 µg/kg per min infusion after induction (30 ml/h).
DRUGSaline
Group S was given a bolus of saline solution in 10 ml volume 10 min before induction of anesthesia, followed by 30 mL/h serum saline infusion.
Sponsors
Karadeniz Technical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Masking description
The surgeon and observers were all blinded to the patients until the end of the study.
Intervention model description
1. First arm received dexmedetomidine 2. Second arm received ketamine 3. Third arm received saline solution.
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient graded as American Society of Anesthesiologist (ASA) physical status, I or II * Patient subjected to septorhineoplasty operation
Exclusion criteria
* Patient having morbid obesity, * Patient having yypertension, * Patient having Asthma, * Patient having neuropsychiatric disease, * Patient allergy to the study drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response to verbal stimulus time | 0-120 minutes following finishing operation | Verbal response received when the patient was spoken to |
| Intraoperative additional fentanyl requirement | 0-120 minutes following initiating operation | Intraoperative additional fentanyl requirement for pain relief and |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | 0-120 minutes | Heart rate during operation and following operation |
Countries
Turkey (Türkiye)
Outcome results
None listed