Pathophysiology of Placenta Accreta
Conditions
Keywords
Netrin-1, neogenin,PAS, zeb-1
Brief summary
The main goal of this study is to assess the role of Netrin 1, neogenin and ZEB1 in PAS-associated invasion
Detailed description
* To evaluate the immunohistochemical expression of these proteins in PAS specimens in comparison with the control placental tissues. * To correlate their expression with the demographic parameters. * To assess the correlation between their expression in PAS specimens.
Interventions
no intervention applied
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* PAS patients who underwent hysterectomy to allow proper pathologic grading of PAS
Exclusion criteria
* patients with fundal and middle anterior or posterior placenta, * pregnancy associated with morbid conditions such as hypertension, diabetes mellitus, autoimmune disease, cardiac disease, renal disease, history of anemia, blood transfusion, other blood diseases and endocrinal disease; fetal distress or intrauterine growth retardation. * uterine scar pregnancies were excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| impact of netrin-1 in the pathophysiology of placenta accreta spectrum | baseline | 1. Evaluation of the immunohistochemical expression of netrin 1 in PAS specimens in comparison with the control placental tissues. 2. Evaluation of the immunohistochemical expression of neogenin in PAS specimens in comparison with the control placental tissues 3. Evaluation of the immunohistochemical expression of ZEB1 in PAS specimens in comparison with the control placental tissues. 4. Correlate their immunohistochemical expression with the demographic parameters and assess the correlation between their expression in PAS specimens. |
Countries
Egypt
Outcome results
None listed