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Prevalence and Risk Factors of COVID-19 in the Upper Silesian Agglomeration

Prevalence and Risk Factors of COVID-19 Infection in the Upper Silesian Agglomeration Population in 2020

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04627623
Acronym
EpiSARS2
Enrollment
6000
Registered
2020-11-13
Start date
2020-06-22
Completion date
2021-04-22
Last updated
2020-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corona Virus Infection, Covid19, Respiratory Tract Disease, Respiratory Tract Infections, RNA Virus Infections, Severe Acute Respiratory Syndrome, Virus Disease

Keywords

Covid19, Risk factors, Prevalence, Mortality, anti-SARS-CoV-2 antibodies

Brief summary

Project is designed as a comprehensive population-based epidemiological study in Upper-Silesian Conurbation (Poland) aiming at: 1. analysis of available data on incidence and mortality due to COVID-19 and 2. estimation of the occurrence of viral infection SARS-CoV-2 as revealed by the results of serological test (ELISA: IgM, IgG), with assessment of risk factors. The project's objectives are: to assess incidence and mortality due COVID-19 according to sex, age and coexisting diseases; to determine the level of potential underdiagnosis of the magnitude of COVID-19 mortality using vital statistics data for Upper-Silesian Conurbation; to assess the prevalence of SARS-CoV-2 based on the level of seropositivity in Upper-Silesian Conurbation; to identify host-related and environmental risk factors if the infection. Analysis of existing data will include monthly records on incidence and mortality over the period 01.01.2020-31.12.2020 and comparison of the findings with the monthly records of 2018 and 2019, for the same population. Cross-sectional epidemiological study will be located in three towne (Katowice, Sosnowiec, Gliwice). In each town a representative age-stratified sample of 2000 subjects will undergo questionnaire assessment and serological examination performed by serological test. The project corresponds with analogous population-based studies on COVID-19 in a number of countries and responds to the WHO recommendation in that field.

Detailed description

Project is designed as a comprehensive population-based epidemiological study in Upper-Silesian Conurbation (Poland) aiming at: 1. analysis of available data on incidence and mortality due to COVID-19 and 2. estimation of the occurrence of viral infection SARS-CoV-2 as revealed by the results of serological test (ELISA: IgM, IgG), with assessment of risk factors. The project's objectives are: to assess incidence and mortality due COVID-19 according to sex, age and coexisting diseases; to determine the level of potential underdiagnosis of the magnitude of COVID-19 mortality using vital statistics data for Upper-Silesian Conurbation; to assess the prevalence of SARS-CoV-2 based on the level of seropositivity in Upper-Silesian Conurbation; to identify host-related and environmental risk factors if the infection. Analysis of existing data will include monthly records on incidence and mortality over the period 01.01.2020-31.12.2020 and comparison of the findings with the monthly records of 2018 and 2019, for the same population. Cross-sectional epidemiological study will be located in three towne (Katowice, Sosnowiec, Gliwice). In each town a representative age-stratified sample of 2000 subjects will undergo questionnaire assessment and serological examination performed by serological test. The project corresponds with analogous population-based studies on COVID-19 in a number of countries and responds to the WHO recommendation in that field.

Interventions

DIAGNOSTIC_TESTIgM and IgG antibodies assay

5 ml venous blood sample collection to assay IgM and IgM against COVID19

Sponsors

Medical University of Silesia
Lead SponsorOTHER

Study design

Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

citizens of one of three towns (Katowice, Sosnowiec, Gliwice) with no age limits

Exclusion criteria

person who is not able to contact laboratory and obtain blood sample. \-

Design outcomes

Primary

MeasureTime frameDescription
Estimation of prevalence of specific anti-SARS-CoV-2 IgM and IgG antibodies in general population.8 monthsEstimation of real prevalence of elevated IgM and IgG COVID antibodies in general population will allow to estimate real number of current and past COVID infection in the population.

Secondary

MeasureTime frameDescription
Frequency of asymptomatic course of COVID in individuals with anti-SARS-CoV2 antibodies8 monthsPrevalence of asymptomatic cases into seropositive population

Countries

Poland

Contacts

Primary ContactGrzegorz M Brozek, Prof
gbrozek@sum.edu.pl0048 693 700 184

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026