The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

The Effect of Arterial Oxygen Levels on Thiol Disulfide Homeostasis and Ischemia Modified Albumin in Coronary Artery Bypass Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04627220

Enrollment

100

Registered

2020-11-13

Start date

2020-01-01

Completion date

2020-11-01

Last updated

2020-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Keywords

cardiovascular surgery, antioxidant, tiyol-disülfid homeostasis, ischemia modified albumin

Brief summary

We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Detailed description

Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Interventions

DIAGNOSTIC_TESTtaken venous sample

Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* patient scheduled for cardiac surgery * ASA\>3 * Aged 18-75 years

Exclusion criteria

* those with valvular disease * EF\<%40 * BMI\>40 kg/m2 * presence of arrhythmia that impairs hemodynamics * previous history of cerebrovascular * diagnosed with end-stage organ failure

Design outcomes

Primary

Measure	Time frame	Description
assessment of oxidative damage	48 hours after operation	To measure the degree of oxidative damage in the patient's blood at different oxygen values used in cardiac bypass surgeries with thiol disulfide homeostasis and ischemia-modified albumin at times determined.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026