Helicobacter Pylori Infection
Conditions
Keywords
Doxycycline, LOAD regimen, Helicobacter Pylori, levofloxacine, tinadizole
Brief summary
Comparison Efficacy of two weeks Therapy with Doxycycline,levofloxacine,Tinadizole Versus Levofloxacine,Tinadizole,Amocillin on Eradication of Helicobacter Pylori in Syrian population.
Interventions
DRUGDoxycycline
Doxycylcine 100 mg bid ,esomprazole 20 bid,levofloxacineq.d,Tinadizole 500 bid
Levofloxacin 500 mg qd, amoxicillin 500 2cab bid,Tinadizole 500 bid, esomprazole 20 bid
Sponsors
Damascus Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods: * Positive rapid urease test (CLOtest). * Histologic evidence of H. pylori by modified Giemsa staining. * Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.
Exclusion criteria
* Children and teenagers aged less than 18 years. * Previous eradication treatment for H. pylori. * Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics. * History of gastrectomy. * Gastric malignancy, including adenocarcinoma and lymphoma, * Previous allergic reaction to antibiotics (Amoxicillin, Tinadizole, * Doxycycline,Bismuth subsalicylate,) and prompt pump inhibitors (Es- omeprazole). * Contraindication to treatment drugs. * Pregnant or lactating women. * Severe concurrent disease. * Liver cirrhosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Eradication rate of Helicobacter pylori infection | 8 week from begning of treatment | Eradication rate of Helicobacter infected patients |
Countries
Syria
Contacts
Primary ContactMarouf MH Alhalabi, MD
Outcome results
None listed