Bladder Cancer, Prostate Cancer, Renal Cell Cancer, Ureter Cancer, Urological Malignancies
Conditions
Brief summary
Genitourinary malignancies such as prostate cancer, renal cell cancer, and bladder cancer in Korean population have been increased due to the aged population and the westernized lifestyles. With the advancement of technologies, studies have found that microbiome not only affects human physiological functions, such as metabolism, immunity, and haematopoiesis, but also plays a significant role in the development and progression of malignancies. However, the investigation of microbiome in urological malignances have been limited and few studies have been reported. Therefore, the investigator tried to evaluate the usefulness of microbiome in detection and monitoring of urological malignancies in Korean population. This study aims to use microbiome in tissue, plasma, stool and urine for the diagnosis, disease progression monitoring and therapeutic response evaluation. This study plan includes building big databases for microbiome of urological malignancies in Korean population.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed as urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) * Patients who have undergone surgeries due to urological malignancies in Severance Hospital, Sinchon from 2020.10 and 2030.10 * Those who agree to give permission to use their human source information * Those who agree with this study
Exclusion criteria
* Those who do not agree with this study * Vulnerable participants who are likely to be vulnerable to coercion or undue influence or lack decision-making
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between tissue bacteria composition and prevalence of urological malignancies | within 2 weeks after the surgery | evaluate and compare the bacteria composition in tissue samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group |
| Correlation between plasma bacteria composition and prevalence of urological malignancies | within 2 weeks after the surgery | evaluate and compare the bacteria composition in plasma samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group |
| Correlation between stool bacteria composition and prevalence of urological malignancies | within 2 weeks after the surgery | evaluate and compare the bacteria composition in stool samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group |
| Correlation between urine bacteria composition and prevalence of urological malignancies | within 2 weeks after the surgery | evaluate and compare the bacteria composition in urine samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of bacteria composition and tumor response assessed using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) | within 10 years after the surgery | Association between bacteria composition and oncological prognosis, progression, and therapeutic response in urological malignancies |
Countries
South Korea
Contacts
Primary ContactWon Sik Ham
Outcome results
None listed