Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04625478

Acronym

CRISBO

Enrollment

Registered

2020-11-12

Start date

2020-12-01

Completion date

2021-12-20

Last updated

2025-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone and Joint Infection, Staphylococcus

Keywords

Bone and Joint Infection, Staphylococcus, intracellulare

Brief summary

Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI. The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

Interventions

OTHERPatients having had an osteo-articular infection with Stahylococcus

Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 95 Years

Inclusion criteria

* patients having had an osteo-articular infection with Staphylococci

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
detection of intracellular staphylococci	2 months	to explore if intracellular staphylococci can be observed on samples of patient having an osteo-articular infection with staphylococci
rate of localisation of intracellular staphylococci	2 months	to explore where in what type of celles they can be observed on samples of patient having an osteo-articular infection with staphylococci

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026