Skip to content

Role of Bronchoscopy in Assessment of Patients With Post-intubation Tracheal Stenosis

Role of Bronchoscopy in Assessment of Patients With Post-intubation Tracheal Stenosis

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04625400
Enrollment
87
Registered
2020-11-12
Start date
2021-01-01
Completion date
2023-04-01
Last updated
2020-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheal Stenosis

Brief summary

1. To estimate the importance of bronchoscopic treatment of tracheal stenosis and its effectiveness and safety. 2. To diagnose and evaluate tracheal stenosis characteristics as location, vertical extension and severity of obstruction.

Detailed description

Post intubation tracheal stenosis (PI) was recognized in 1880, after prolonged endotracheal intubation in 4 patients with upper airway obstruction.The most common causes of acquired tracheal stenosis are endotracheal intubation and tracheostomy. Tracheal stenosis is a surgical problem managed non operatively by bronchoscopic dilation, endoluminal treatment with lasers, and stenting. Bronchoscopic management have a good success rate. PI and post tracheostomy stenosis (PT) are recognized with an 4.9 cases per million per year in the general population. Prolonged intubation can result in tracheal stenosis at various levels within the trachea.Tracheal stenosis occurs at the endotracheal tube cuff site in one third of the reported PI cases \[9\] and appears as a web-like fibrous. The mainly postulated cause is loss of regional blood flow.This injury begins within the first hours of intubation, and healing of the damaged areas within 3 to 6 weeks. Large volume, low pressure cuffs has reduced the occurrence of cuff injury.Patients in the ICU are common to have respiratory involvement, with 30-50% of the admissions requiring the use of mechanical ventilation.Flexible bronchoscopy has become the procedure of choice in most examinations of the tracheobronchial tree.The incidence of PI tracheal stenosis ranges from 6-21% and following tracheostomy ranges from 0.6-21%.

Interventions

DIAGNOSTIC_TESTbronchoscope

Bronchoscopy in Assessment of Patients With Post-intubation Tracheal Stenosis.

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

1. Meticulous History and Clinical Examination 2. Chest x-Ray (CXR) 3. Spirometry 4. Flexible bronchoscopy 5. Rigid Bronchoscopy (when needed).

Exclusion criteria

1. Patient refusal. 2. Any coagulation disorder. 3. Untreatable life-threatening arrhythmias. 4. Allergy to anaesthesia. 5. Poor general condition.

Design outcomes

Primary

MeasureTime frameDescription
tracheal stenosis incidence in ICU cases after mechanical ventilation2 yearsincidence of tracheal stenosis among ICU cases after mechanical ventilation assessed by flexible bronchoscope measured by numbers.(patients/year)

Secondary

MeasureTime frameDescription
the location, degree of tracheal stenosis characteristics.2 years1. identify the location of stenosis: - upper-third of the trachea (I) from 1-4 cm middle-third of the trachea (II) from 5-8 cm lower-third of the trachea (III)from 9-12 cm by Chest x-Ray (Chest x-ray) 2. the diameter of trachea was assessed by cm. 3. Spirometry by measuring the ratio of forced expiratory volume (FEV 1 ) in 1 second to peak expiratory flow (PEF). 4. FEV 1 measured in in milliliter ,FEV1/FVC ratio.

Contacts

Primary ContactMohamed k Mohamed, phd
mkdarwish90@hotmail.com01098989377
Backup ContactRafaat T El-Sokry, professor
Elsokkary100@yahoo.com01006155517

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026