COMT Activity and Hypnotizability

COMT Activity as a Biomarker for Hypnotizability and Hypnotic Analgesia Using a Multiplexed Precision Medicine Platform

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04624880

Enrollment

Registered

2020-11-12

Start date

2021-01-13

Completion date

2021-07-13

Last updated

2026-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genetic Predisposition, Pain, Postoperative

Keywords

Hypnosis, Biosensing, technique, Pain, psychology, Analgesia,psychology, Hypnotizability, Giant Magnetoresistive Sensors

Brief summary

Hypnosis is an effective pain management tool for surgery that can reduce opioid use up to 40%. COMT single nucleotide polymorphisms (SNPs) can predict pain sensitivity and opioid use perioperatively, and may also be associated with hypnotizability or response to hypnotic analgesia. Analyzing COMT haplotypes from DNA extracted from saliva or blood using a giant magnetoresistive (GMR) nanotechnology platform may be faster, less expensive, and at least as accurate as pyrosequencing. This study aims to validate a multi-SNP point-of-care (POC) GMR assay for the rapid genotyping of SNPs predictive of COMT activity, and test the feasibility of using COMT activity as a biomarker for hypnotizability and/or response to hypnotic analgesia.

Interventions

DEVICEGiant magnetoresistive sensor (GMR)

Giant magnetoresistive sensor analyzes genetic polymorphisms in patient samples.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Prior enrollment in one of 3 specific hypnosis trials * Enrollment is by invitation only

Exclusion criteria

* Participants in the prior trials who declined to be contacted for future research.

Design outcomes

Primary

Measure	Time frame	Description
Percent concordance of rapid genotyping of SNPs with giant magnetoresistive sensors vs. genotyping using pyrosequencing	Through study completion, average of 2 years	We will test the hypothesis that the four COMT SNPs (rs4680, rs4818, rs4633, and rs6269) can be detected on the GMR platform with 99% accuracy when compared to pyrosequencing
Determine which COMT SNP haplotypes associate with high/medium/low hypnotizability measured by the Hypnotic Induction Profile score.	Through study completion, average of 2 years	—

Secondary

Measure	Time frame	Description
Determine which COMT diplotypes/haplotypes associate with high/medium/low postoperative opioid use in milligram morphine equivalents/hour/kilogram of body weight (MME/kg/hr), and high/medium/low average pain scores on the Numeric Pain Scale.	Through study completion, average of 2 years	Determine if there is a relationship between COMT diplotypes/haplotypes and pain or opioid use in a subgroup of patients who underwent hypnosis prior to knee replacement surgery vs. patients in the control group who were not hypnotized, during their inpatient admission postoperatively

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORShan Wang, PhD

Stanford University

PRINCIPAL_INVESTIGATORDavid Spiegel, MD