Menopause, Oxidative Stress
Conditions
Brief summary
Thiol disulfide levels will be determined using venous blood samples from pre- and postmenopausal women to evaluate oxidative stress in menopause. Furthermore, oxidative stress will be assessed according to age, and years since the start of menopause. Also, whether the presence of menopause related osteoporosis has any association with oxidative stress will be determined.
Detailed description
A total of 77 subjects are divided into two groups: study group (postmenopausal women) and control group premenopausal women). Biometric data such as age, bmi, obstetric anamnesis, history of komorbidities, PAP smear results are recorded. Mammography results, dexa scores of post menopausal women are also obtained. Venous blood samples from all subjects are collected. Thiol disulfide levels will be determined from serum samples. Thiol disulfide levels will first be compared between the study and the control group in order to determine the oxidative stress in menopause. In secondary evaluation years of menopause, age, and dexa scores will be included.
Interventions
OTHERThiol disulfide level
Venous blood is collected from all subjects and thiol disulfide levels will be determined from the serum samples obtained from the venous blood.
Sponsors
Sisli Hamidiye Etfal Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Women who entered menopause as a natural process Women within the age limits Still menstruating healthy women as control subjects
Exclusion criteria
Women who have entered menopause prematurely Women who have entered menopause following a surgery Women with medically induced menopause Women without any autoimmune or chronic inflammatory diseases Women who are taking hormone replacement therapy due to menopausal symptoms Women without any malignant diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluating Oxidative Stress in Menopause | 2 months | Thiol disulfide stress will be evaluated using serum samples from postmenopausal women and comparing these results with samples obtained from premenopausal women. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluating Oxidative Stress According to Years of Menopause | 2 months | Thiol disulfide levels will be determined and analysis will be done according to the years of menopause |
| Evaluating Oxidative Stress According to Menopause Related Osteoporosis | 2 months | Thiol disulfide levels will be determined and analysis will be done according to the osteoporosis scores evaluated with dxa |
Countries
Turkey (Türkiye)
Outcome results
None listed