Gastric Cancer
Conditions
Brief summary
The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.
Detailed description
This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.
Interventions
DIAGNOSTIC_TESTdifferent diseases
Patients will be divided into three groups, including chronic superficial gastritis ,chronic atrophic gastritis and gastric carcinoma.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients with chronic superficial gastritis and chronic atrophic gastritis * Patients with gastric carcinoma
Exclusion criteria
* Patients with history of surgery * Patients with severe heart disease,lung disease or kidney disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabonomic difference in patients with chronic gastritis and gastric carcinoma | six months | 1.The different levels of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma. 2. The common change model of metabolites in gastric carcionoma compared with chronic gastritis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of different metabolic substances and disease results in chronic gastritis and gastric carcinoma | six months | The researchers want to reveal the relationship between different metabolic sustances and disease result in patientswith chronic gastritis and gastric carcinoma. |
Countries
China
Contacts
Primary ContactYuehua Han, Dr.
Outcome results
None listed