Erectile Dysfunction
Conditions
Brief summary
Erectile dysfunction (ED) is the persistent inability to attain and maintain a sufficient erection to permit satisfactory sexual performance. ED, a condition closely related to cardiovascular morbidity and mortality, is frequently associated with obesity. The importance of reducing cardiovascular risk factors remains fundamental to the overall vascular good health of the man, and that includes sexual vascular health. ED shares similar modifiable risks factors with coronary artery disease (CAD). Lifestyle modification that targets CAD risk factors may also lead to improvement in ED.
Detailed description
Sixty obese men with ED complaints will be divided to two groups, exercised and non-exercised groups; n= 30 patients in every group. Both groups will receive five milligrams of tadalafil one time per day for 8 weeks but the exercised group only will receive - in addition to tadalafil - combined continuous and interval aerobic training, 3 session weekly for 8 weeks after detecting their target heart rate via the cardiopulmonary exercise test.
Interventions
OTHERTadalafil 5Mg Tab + continuous and interval exercise
(n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, in addition to 3 sessions, per week, of combined continuous and interval aerobic exercise for eight weeks
(n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, for eight weeks
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
40 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Sixty sedentary obese married men with BMI \> 30 kg/m2. 2. The age of participants will range from 40-50 years old. 3. Blood pressure will be \< 140/90 mm Hg. 4. The patients who will have ED at least from 6 months with IIEF-5 score \< 22.
Exclusion criteria
1. Alcoholic, smoker, hypertensive, diabetic, and addicted patients. 2. Patients with pulmonary, renal, hepatic, and cardiac disorders. 3. Lower limb arthritis or orthopaedic disorders that will hinder the training program. 4. Prostatic inflammation, hyperplasia, and tumors. 5. Participation in a structured sport program in the previous 6 months. 6. previous pelvic and genital surgeries.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Five-Item Version of International Index of Erectile Function (IIEF-5) | It will be measured after eight weeks of training | It is a questionnaire of five questions to diagnose ED in male patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Triglycerides | It will be measured after eight weeks of training | It will be measured via a venous blood sample |
| High density lipoprotein | It will be measured after eight weeks of training | It will be measured via a venous blood sample |
| Insulin | It will be measured after eight weeks of training | It will be measured via a venous blood sample |
| Fasting blood glucose | It will be measured after eight weeks of training | it will be measured via a blood glucose meter |
| The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance | It will be measured after eight weeks of training | HOMA-IR = \[fasting insulin (μU/mL) × fasting glucose (mmol)\]/22.5 |
| body mass index | It will be measured after eight weeks of training | It will be obtained by dividing the weight in Kilograms on the squared height in meter |
| systolic blood pressure | It will be measured after eight weeks of training | it will be measured by a manual sphygmomanometer |
| diastolic blood pressure | It will be measured after eight weeks of training | it will be measured by a manual sphygmomanometer |
| Waist circumference | It will be measured after eight weeks of training | it will be measured by inelastic tape at the umbilicus level |
Countries
Egypt
Contacts
Primary ContactAli Ismail, lecturer
Outcome results
None listed