Constipation
Conditions
Keywords
high resolution manometry
Brief summary
Constipation is a frequent symptom that is reported by more than 10% of the general population. In a few case, constipation is resistant to medical standard care, including osmotic and stimulant laxatives. The diagnosis of colonic inertia may be suspected in these patients although diagnostic criteria for colonic inertia may vary from one country to another. In France, the diagnosis of colonic inertia is based on manometric study of the colorectal contractile activity using manometric probe. Using conventional manometric catheters, severe alteration of the colorectal motility is found in a very small subset of patients, who may later benefit from surgery. The recent use of high resolution manometric probe allowed to map more precisely colorectal motility, but whether these new parameters are relevant remains to be assessed. The aim of this study is to assess the diagnostic performance of a new high resolution manometric probe by comparing healthy volunteers to patients suspected of colonic inertia.
Interventions
High resolution manometry
Sponsors
University Hospital, Rouen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
For patient Inclusion Criteria: * Age between 18 and 65 years * chronic Constipation (\> 6 months) * delayed colonic transit time \> 100 h * normal colonoscopy * constipation refractory to at least 1 osmotic and 1 stimulant laxative according French guidelines on constipation ; * Affiliated to French national healthcare insurance
Exclusion criteria
* Patient with constipation being either: * With colonic transit time \<100h * Distal (with radio-opaque markers stasis in the rectum) * From organic origin * Recent (\<6 mois) * Relieved using osmotic or stimulant laxatives * Contra-indication to the use of high resolution manometry insertion * Intestinal occlusion * Coagulation disorders, including anti-coagulant treatments * General anesthesia contra-indication * colonoscopy contra-indication * failure to perform a colonoscopy in previous attempts * medication intake that may impair colorectal motility, including opioids * Evolutive inflammatory of neoplasia process * History of major digestive surgery (at exclusion of appendicectomy, cholecystectomy) * Presence of condition that may impact digestive motility, including diabetes mellitus and sclerodermia * Cardiologic disease that may represent a contraindication to vagal stimulation For Healthy volunteers Inclusion Criteria: * Age between 18 and 65 years * Affiliated to French national healthcare insurance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of isolated propagated colonic contractions | 24 hours | Number of colonic contractions during 24 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Speed of isolated propagated colonic contractions | 24 hours | Average speed of colonic contractions during 24 hours |
| Colonic transit time | during the first 24 hours | Transit time will be measured during during the first 24 hours |
Countries
France
Contacts
CONTACTGuillaume GOURCEROL, Pr
CONTACTJulien BLOT
PRINCIPAL_INVESTIGATORGuillaume GOURCEROL
University Hospital, Rouen
Outcome results
None listed