Cognition, Covid-19
Conditions
Brief summary
This study is carried on in Wuchang Hospital in Wuhan, China. The investigators plan to recruit 80 patients with COVID-19 and 80 matched healthy control. Using the design of case-control study, the study aims to assess the neurocognitive functions such as executive function and attentional bias in recovered patients with COVID-19 under normal and stress conditions, and to analyze the influencing factors of neurocognitive functions, such as mental health conditions, inflammation indicators and cardiopulmonary function.
Interventions
BEHAVIORALTrier Social Stress Test
8-min oral calculation and 5-min speech
Sponsors
Peking University Sixth Hospital
Wuhan Wuchang Hospital
National Institute on Drug Dependence, China
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Recovered COVID-19 patients or uninfected residents in Wuhan, with an education level above elementary school and are able to complete cognitive tasks; * Willing to participate in this study and sign informed consent.
Exclusion criteria
* Subjects with body temperature\> 38°C; * Subjects who are in menstruation and pregnancy; * Subjects suffering from cardiopulmonary diseases before the new coronary pneumonia epidemic (such as heart disease, pulmonary hypertension, congestive heart failure, etc.); * Subjects with severe disturbances in consciousness, cognitive dysfunction, mental disorders, visual and hearing disorders, bone and joint diseases, etc.; * Subjects with abnormal immune system and severe organ dysfunction (heart, liver, kidney, etc.); * Subjects who are unwilling to participate in this study and cannot complete all surveys and cognitive function tests.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| working memory | 10 minutes | assessed by the n-back task, including 0-back, 1-back and 2-back |
| Cognitive flexibility | 3 minutes | assessed by the trail-making task |
| Inhibitory control | 10 minutes | assessed by the stroop task |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum IL-6 | 1 day | Concentration of serum IL-6 in ng/ml will be assessed by ELISA. |
| CRP | 1 day | hypersensitive C-reactive protein(hs-CRP) in mg/L will be assessed by Turbidimetric inhibition immuno assay. |
| Depression | 3-5 minutes | assessed by Self-Rating Depression Scale, which is consist of 20 items scoring 1 to 4. |
| PTSD | 3-5 minutes | assessed by PTSD Checklist for DSM-5 (PCL-5) |
| Sleep | 3-5 minutes | assessed by Pittsburgh sleep quality index (PSQI) |
| General cognition | 8-10 minutes | assessed by Montreal - Cognitive Assessment (MoCA) |
| Cardiopulmonary function 1 | 15 minutes | maximal inspiration pressure（MIP), maximal expiration pressure（MEP） |
| Cardiopulmonary function 2 | 10 minutes | Assessed by the 6-minutes' walk test |
| Anxiety | 3-5 minutes | assessed by Self-Rating Anxiety Scale, which is consist of 20 items scoring 1 to 4. |
| Attention Bias | 15 minutes | assessed by the dot-probe task |
| Serum TNFalpha | 1 day | Concentration of serum TNFalpha in ng/ml will be assessed by ELISA |
Other
| Measure | Time frame | Description |
|---|---|---|
| Stress response indicator 1 | Saliva samples will be colleted before stress, 0 minutes and 10 minutes after stress. | concentration of saliva cortisol stress, assessed by ELISA |
| Stress response indicator 3 | Assessed before and 0 minute after stress | Blood pressure before stress and after stress |
| Stress response indicator 2 | Assessed before and 0 minute after stress | Hear rates |
Countries
China
Contacts
Primary ContactPing Wu, Dr.
Outcome results
None listed