Acute Kidney Failure Stage 3, Acute Kidney Injury
Conditions
Keywords
Ultrasound, Renal Replacement Therapy, Dialysis, Renal Doppler Ultrasound
Brief summary
Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT). Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.
Interventions
OTHERDialysis weaning
Dialysis weaning as planned by the attending ICU-physician.
Sponsors
Johan Fridolf Hermansen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients ≥ 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning
Exclusion criteria
* Insufficient ultrasonographic imaging of the kidneys * Known morphological kidney disease * Previous need of chronic RRT * Prior participation in the study * Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dialysis weaning | 7 days | If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Renal Doppler Renal Venous Stasis Index (RVSI) | Measured at the beginning of weaning and after 6 hours. | Measured in the interlobar vessels |
| Renal Doppler Venous Impedance Index (VII) | Measured at the beginning of weaning and after 6 hours. | Measured in the interlobar vessels |
| Renal Doppler arterial Resistive Index (RI) | Measured at the beginning of weaning and after 6 hours. | Measured in the interlobar vessels |
| Urine Output | 4 days | — |
| Urine Creatinine Clearance | 4 days | — |
| Portal vein Doppler Pulsatility Fraction PF) | Measured at the beginning of weaning and after 6 hours. | Measured in the interlobar vessels |
Countries
Denmark
Outcome results
None listed