Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04620941

Enrollment

Registered

2020-11-09

Start date

2022-02-21

Completion date

2023-12-21

Last updated

2024-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated Pneumonia (VAP)

Keywords

Ventilator-associated pneumonia, reticulocyte/hemoglobin ratio, neutrophil/lymphocyte ratio

Brief summary

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Detailed description

Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit, affecting one third of patients requiring mechanical ventilation for a noninfectious reason. In the case of inflammation, iron retention increases in the reticuloendothelial system cells; hemoglobin (Hb) synthesis is reduced. It has been reported that the ratio of reticulocyte / hemoglobin (Ret-He) decreases in the early period in community-acquired pneumonia patients and may be a guide as a marker of inflammation. In addition, the neutrophil / lymphocyte ratio (NLR) is a parameter studied in the hemogram panel. It provides a clue to both the presence of infection and the focus of the infection. In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Interventions

DIAGNOSTIC_TESTreticulocyte/hemoglobin (Ret-He) ratio

Ret-He values will be studied on the day (1st day), 4th and 7th days of the diagnosis of ventilator-associated pneumonia in patients hospitalized in the intensive care unit.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Inclusion criteria

-Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit

Exclusion criteria

* Pulmonary or extrapulmonary infection before mechanical ventilation, * severe immunosuppression, * bleeding in the gastrointestinal system, * using corticosteroids, * neoplastic disease history

Design outcomes

Primary

Measure	Time frame	Description
Early inflammation markers for VAP	7 days	To investigate the use of NLR and Ret-He value as early inflammation markers for VAP.

Secondary

Measure	Time frame	Description
morbidity and mortality	7 days	To compare the effects of Ret-He and NLR values on morbidity and mortality with other inflammation markers

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026