Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04620928

Enrollment

Registered

2020-11-09

Start date

2021-08-02

Completion date

2023-01-31

Last updated

2023-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia

Brief summary

This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.

Detailed description

This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.

Interventions

BEHAVIORALConcepts

Images and sounds that are characteristic of various common objects.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Intervention model description

Present a behavioral intervention to a single group of participants and measure subsequent electrical activity in the brain.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinically determined to require an awake left temporal resection of a brain lesion with concurrent language testing. * English as a first language.

Exclusion criteria

* Significant preoperative neuropsychological deficits in memory or naming. * Patients with inability to make decisions regarding their participation in this research project. * Surgeon does not plan to expose the area of interest or determines that recording during the resection will interfere with his surgical plan.

Design outcomes

Primary

Measure	Time frame	Description
Brain activity	Recorded immediately during experiment	Electrocorticographic brain activity measured from brain surface

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026