Coronavirus Infection, Human ARDS
Conditions
Keywords
Post-intensive care Syndrome, Acute Respiratory Distress Syndrome, quality of life, intensive care unit, PTSD, follow-up after ICU, COVID-19
Brief summary
For the last years, studies have described the Post-intensive care Syndrome (PICS), which consists in alteration of quality of life, cognition, autonomy and psychological disorders within the months after intensive-care. Patients with COVID-19 in intensive care units are at high risks to develop PICS. The primary objective is to analyse the incidence of the post-traumatic stress disorder at 12 months after intensive-care for a COVID-19 Acute Respiratory Distress Syndrome (ARDS).
Detailed description
Many studies have showed that ARDS survivors keep, even a long time after hospitalization, a functional respiratory disability, resulting on one hand from impaired diffusion of carbon monoxide, and on the other hand from a muscular weakness. Indeed, 67% of patients ventilated more than 10 days have a neuromyopathy whose recovery is uncertain. Beside this, Long-term quality of life is worse than in general population, due in particular to depressive and anxiety disorders such as post-traumatic syndrome disorder with a prevalence around 22% after one year. The follow-up will consist in phone call with an intensive care doctor. These visits would be the opportunity to screen the complications after intensive-care with, find solutions to cure them or decrease their impact on patient's life to improve quality of life and prevent the post-traumatic syndrome disorder PTSD. A review would be sent to the patients' General Practitioners at the end of each visit.
Interventions
OTHERFollow up calls
The follow-up will consist in phone call with an intensive care doctor. These visits would be the opportunity to screen the complications after intensive-care with, find solutions to cure them or decrease their impact on patient's life to improve quality of life and prevent the post-traumatic syndrome disorder PTSD. A review would be sent to the patients' General Practitioners at the end of each visit.
Sponsors
University Hospital, Toulouse
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patient * hospitalized in intensive care of the CHU anesthesia-intensive care unit (Rangueil, URM, Neurosurgery) * intubated and ventilated * supported for an ARDS according to the Berlin criteria (PaO2 / FiO2 ratio \<300 mmHg) * with an rt-PCR positive to SARS-CoV-2 * affiliated to the french social security
Exclusion criteria
* minor patient * patient under protective measure * ARDS in the pandemic context but rt-PCR negative to SARS-CoV-2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Post-traumatic Stress Disorder (PTSD) with the Post-traumatic Checklist-5 (PCL-5) 12 months after intensive-care | month 12 | Incidence of Post-traumatic Stress Disorder (PTSD) with the Post-traumatic Checklist-5 (PCL-5) 12 months after intensive-care |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| psychological disorders measured by QIDS | Month 3 | psychological disorders measured by QIDS, Quick Inventory of Depressive Symptomatology. results from 0 to 27; 27 is the higher score of depressive symptoms |
| psychological disorders measured by STAI-YA | Month 3 | psychological disorders measured by STAI-YA, State Trait Inventory Anxiety. Results from 20 to 80. 80 is the higher score of anxiety |
| quality of life by EQL-5 | Month 3 | Quality of life measured by European Quality of Life -5 scale (overall satisfaction of Europeans concerning different aspects of life) higher score is higher quality of life |
| nutritional status | Month 3 | nutritional status measured by Nutritional Risk Screening 2002 |
Countries
France
Outcome results
None listed