Blepharospasm, Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid, Blepharospasm Oromandibular Dystonia, Meige Disease, Meige Syndrome, Meigs Syndrome, Meig Syndrome
Conditions
Keywords
deep brain stimulation, DBS, DBNL, GPi, pallidotomy
Brief summary
In this study, we will compare the degree of postoperative symptom improvement, postoperative complication rate, postoperative quality of life improvement degree of patients with Meige syndrome undergoing pallidotomy (unilateral globus palliotomy) and deep brain stimulation (unilateral globus pallidus) ,in order to get the conclusion of the comparison of the clinical efficacy of the two surgical plans. In addition, possible predictive factors such as age, gender, age of onset, length of disease course, scale baseline score, preoperative brain PET-CT function analysis and other possible predictive factors are added for analysis, in order to find predictive factors that can guide the choice of surgical options.
Interventions
PROCEDUREpallidotomy
deep brain nuclei lesion of GPi
PROCEDUREdeep brain stimulation
deep brain stimulation of GPi
Sponsors
Peking University People's Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients confirmed Meige sydrome
Exclusion criteria
* Patients who cannot finish the neurosurgery or the postoperative evaluation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Symptom | 2 years | spasm of eyelid |
| complications | 2 years | Postoperative complications |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| quality of life | 2 years | Evaluate using SF-36 |
| depression scale | 2 years | Evaluate using Hamilton Depression Scale |
Countries
China
Outcome results
None listed