Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04618302

Enrollment

Registered

2020-11-05

Start date

2020-10-19

Completion date

2021-01-01

Last updated

2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

lung diffusing capacity for nitric oxide, lung function testing

Brief summary

This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

Detailed description

The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy * Age 18 yrs and older * Ability to follow study procedures and instructions in German

Exclusion criteria

* Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc) * Obesity (BMI \> 30kg/m2) * Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination) * Mental impairment leading to inability to cooperate * Respiratory infection in the last two weeks * Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio \< lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Design outcomes

Primary

Measure	Time frame	Description
Diffusing capacity for nitric oxide (DLNO)	At second study visit	DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

Secondary

Measure	Time frame	Description
Diffusing capacity for nitric oxide (DLNO)	At second study visit	DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.
Diffusing capacity for carbon monoxide (DLCO)	At second study visit	DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.
Alveolar volume (VA)	At second study visit	VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.
Breath hold time (BHT)	At second study visit	BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.

Countries

Switzerland

Outcome results