Ventricular Premature Complexes
Conditions
Brief summary
Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?
Interventions
PROCEDUREInvasive cardiac electrophysiological study and ablation therapy
Invasive cardiac electrophysiological study with cathecholamine provocation and pacing procedures, as well as standard 3D mapping and PVC ablation
DIAGNOSTIC_TESTCardiopulmonary exercise testing
Standard ergometer bicycle test
DIAGNOSTIC_TESTCardiac MRI
Cardiac MRI with cine-imaging and late-gadolinium enhancement
DIAGNOSTIC_TESTHolter monitoring
24h 5 lead or 12 lead ECG recording
DIAGNOSTIC_TESTTransthoracic echocardiography
2D echocardiography
DIAGNOSTIC_TESTCoronary angiography
Conventional invasive coronary angiography or CT angiography as indicated
Sponsors
University of Oslo
Oslo University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Patients referred for PVC ablation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI-based evidence of structural heart disease | 3-5 years | Evidence of structural heart disease from MRI compared to echocardiography |
| PVC induction vs PVC/HR-relationship | 3-5 years | Correlation of method for induction of PVCs during invasive procedure vs PVC/HR relationship during CPET |
| EPS-based evidence of structural heart disease | 3-5 years | Evidence of structural heart disease from invasive electrophysiology vs MRI and echo |
Countries
Norway
Contacts
Primary ContactMathis K Stokke, MD PhD
Outcome results
None listed