Anesthesia
Conditions
Brief summary
Two-handed mask ventilation has been shown to provide higher tidal volume than one-handed mask ventilation. The effects of the two techniques on respiratory mechanics during induction of general anesthesia, however, still need to be determined.
Detailed description
Mask positive pressure ventilation always causes the changes of respiratory mechanics such as ventral redistribution of regional ventilation, which impairs gas exchange. Two-handed mask ventilation has been shown to improve gas exchange by providing higher tidal volume than one-handed mask ventilation. We hypothesis that those higher tidal volume caused by two-handed mask ventilation would also improve the respiratory mechanics during induction of general anesthesia.
Interventions
OTHEROne-handed mask ventilation
Using one-handed mask ventilation techniques during induction of general anesthesia
OTHERTwo-handed mask ventilation
Using two-handed mask ventilation techniques during induction of general anesthesia
Sponsors
Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Scheduled for elective surgery with general anesthesia * American Society of Anesthesiologist (ASA) physical class of I-II.
Exclusion criteria
* acute and chronic respiratory disorders, including chronic obstructive * pulmonary disease (COPD) and asthma; * a history of lung surgery; * exist risk of reflux and aspiration; * patients requiring an awake intubation; * facial and thoracic deformities; * implants exist in the body, such as cardiac pacemakers; * pregnant women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| global inhomogeneity (GI) | 8 weeks | EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. 0% = homogenous |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Expiratory tidal volume (TV) | 8 weeks | Expiratory tidal volume will be recorded through the anesthesia machine. |
| centre of ventilation (CoV) | 8 weeks | EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. 100% = entirely dorsal. |
| regional ventilation delay (RVD) | 8 weeks | EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. |
| ventilation of regional lung ( %) | 8 weeks | EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. |
| PaO2/FiO2 | 8 weeks | PaO2/FiO2 will be recorded through arterial blood gas analysis. |
Contacts
Primary ContactJun Zhang, PhD
Backup ContactLi Yang, MD
Outcome results
None listed